Studies on Anti-Diarrhoeal Activity of Citrus sinensis Peel Extract


  • Vels University, Department of Pharmacology, Vel's College of Pharmacy, Chennai, Tamilnadu, 600117, India
  • Vels University, Vel's College of Pharmacy, Chennai, Tamilnadu, 600117, India
  • Govt. Arts and Science College for Women, Bargur, Tamilnadu, 635104, India


The methanolic extract of the Citrus sinensis peel was screened for antidiarrhoeal activity using animal models against castor oil induced diarrhoea. The parameters evaluated are small intestine secretion by enteropooling assay, rate of defecation and small intestine transit. The methanolic extract showed significant activity (p<0.05) against castor oil induced diarrhoea and interluminal accumulation of fluid. It also reduced gastrointestinal motility after charcoal meal administration in albino mice. The results indicates that the action of Citrus sinensis peel extract (CSPE) could be through a combination of inhibition of elevated prostaglandin biosynthesis and reduced propulsive movement of the small intestine.


Citrus sinensis, Anti-Diarrhoeal, Albino Mice, Castor Oil and Charcoal Meal.

Subject Discipline

Pharmacy and Pharmacology

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