Isolation, Characterization and Anti-Fertility Activity of the Active Moiety from the Seeds of Ensete superbum Cheesm (Banakadali)

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  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2009/215

Keywords:

Ensete superbum Cheesm, NMR, Chroman-2, 7-diol, Anti-Implantation, Anti-Estrogenic and Anti-Ovulatory Activity.
Therapeutic Drug Monitoring

Abstract

The ethanolic extract of the seeds of Ensete superbum Cheesm (Family Musaceae) furnished a compound with structure established as 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2, 7-diol on the basis of physical and spectral basis. The anti-implantation activity of the ethanolic extract at doses of 100, 125 and 250 mg/kg body weight when administered on days 1-7 were 86.9, 94.4, and 98.8% respectively, as compared to the isolated fraction at doses of 2.5 and 5 mg/kg body weight was 87.5 and 96.0% respectively as compared to their Control group. The isolated fraction was found to exhibit significant anti-estrogenic activity in immature female rats at the dose of 5 mg/kg, and the ethanolic extract exhibited very significant activity at the dose of 250 mg/kg-body weight. Histopathological studies revealed significant anti-ovulatory activity in immature female rats at the dose 5 mg/kg. The oral LD50 value of the ethanolic extract of Ensete superbum Cheesm was found to be 3235.9 mg/kg.

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Published

2009-01-01

How to Cite

Kachroo, M., & Agrawal, S. S. (2009). Isolation, Characterization and Anti-Fertility Activity of the Active Moiety from the Seeds of <I>Ensete superbum</I> Cheesm (Banakadali). Journal of Natural Remedies, 9(1), 12–20. https://doi.org/10.18311/jnr/2009/215

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