Anti-Hyperglycemic and Anti-Lipidperoxidative Effects of Tephrosia purpurea leaf Extract in Streptozotocin Induced Diabetic Rats

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  • ,IN
  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2007/193

Keywords:

Tephrosia Purpurea, Streptozotocin, TBARS, Anti-Oxidants, TpALet.
Therapeutic Drug Monitoring

Abstract

Objective: The main objective of the present study was to evaluate the anti-hyperglycemic and anti-lipidperoxidative effects of Tephrosia purpurea leaves (TpALet) in streptozotocin induced diabetic rats. Materials and Methods : The aqueous extract of Tephrosia purpurea leaves was evaluated for its anti-hyperglycemic and antilipidperoxidative effects in streptozotocin (50mg/kg bw) induced diabetic rats. The anti-hyperglycemic effect of the leaf extract was also compared with the standard anti-diabetic drug glibenclamide (600μg/kg bw). Glucose, glycosylated hemoglobin, total hemoglobin, lipid peroxidation by products (TBARS), enzymatic and non-enzymatic anti-oxidants in blood sample and hexokinase and glucose-6-phosphatase activities in liver were estimated calorimetrically in control and experimental animals. Results: "TpALet" considerably reduced the levels of blood glucose, glycosylated hemoglobin and enhanced the status of total hemoglobin, anti-oxidants and hepatic hexokinase and glucose-6-phosphatase activities. "TpALet" also showed a comparable effect to that of glibenclamide. Conclusion: Our results indicate that T. purpurea leaves have potent anti-hyperglycemic and anti-lipidperoxidative effects, which are probably due to its anti-oxidants effect.

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Published

2007-01-01

How to Cite

Pavana, P., Manoharan, S., & Sethupathy, S. (2007). Anti-Hyperglycemic and Anti-Lipidperoxidative Effects of <I>Tephrosia purpurea leaf</I> Extract in Streptozotocin Induced Diabetic Rats. Journal of Natural Remedies, 7(1), 43–49. https://doi.org/10.18311/jnr/2007/193

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