Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus


Affiliations

  • Diacon Hospital Bangalore, Bangalore, Karnataka, 560010, India
  • Management and Science University, Department of Biochemistry, International Medical School, Shah Alam, Selangor, 40100, Malaysia
  • A J Institute of Medical Sciences, Department of Biochemistry, Mangalore, Karnataka, 575004, India
  • Management and Science University, Department of Otolaryngology, International Medical School, Shah Alam, Selangor, 40100, Malaysia

Abstract

Aim: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus.

Materials and Method: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose.

Result: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol).

Conclusion: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.


Keywords

Adenosine Deaminase, Diabetes Mellitus Type 2, Glycated Haemoglobin.

Subject Discipline

Chemistry

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