TY - JOUR AU - Arora, Sweta AU - Haldar, Chandana AU - Basu, Priyoneel AU - Singh, Jasmeet AU - Gupta, Sameer PY - 2022/11/25 Y2 - 2024/03/28 TI - Oral Administration of Root Extract of Boerhaavia diffusa Mitigates Diabetes-induced Kidney Damages in the Golden Hamster Mesocricetus auratus JF - Journal of Endocrinology and Reproduction JA - JER VL - 26 IS - 3 SE - Original Research DO - 10.18311/jer/2022/30129 UR - https://www.informaticsjournals.com/index.php/jer/article/view/30129 SP - 163-170 AB - <p>Diabetes, a common metabolic disorder, is affecting people irrespective of age group and/or gender. The chronic hyperglycemia during diabetes leads to heart-, kidney-, eye- and nerve damages. <em>Boerhaavia diffusa</em>, commonly known as Punarnava, is one of the traditional medicines described in Ayurveda for the treatment of a number of diseases. <em>B. diffusa</em> has been reported to exhibit antidiabetic, diuretic, anti-inflammatory, hepatoprotective, and immunomodulatory properties. The present study was carried out to evaluate the anti-hyperglycemic potential of ethanolic extract of root of <em>B. diffusa</em> and its effect on diabetes-induced kidney damage in hamster model. Treatment of ethanolic extract of<em> B. diffusa</em> resulted in significant reduction in the serum glucose level and increased insulin concentration with a simultaneous increment in the levels of muscle and liver glycogen. The oral supplementation of <em>B. diffusa</em> root extract improved lipid profile by reducing the cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and by increasing high density lipoprotein cholesterol (HDL-C). The activity of antioxidant enzymes Superoxide Dismutase (SOD) and Catalase (CAT) in the kidney significantly improved following oral administration of <em>B. diffusa</em> while a significant decrease in Lipid Peroxidation (LPO) level was noted in the kidney after the treatment. Ethanolic root extract of <em>B. diffusa</em> decreased the level of serum creatinine, urea and Alkaline Phosphatase (ALP) significantly. <em>B. diffusa</em> administration demonstrated marked improvement in renal histology as evident by the regenerative changes in glomerulus and Bowman’s capsule. Thus, the use of ethanolic extract of <em>Boerhaavia diffusa</em> may prove therapeutically effective in prevention as well as inhibition of the progression of diabetes and associated kidney damages.</p> ER -