Serum Dihydrotestosterone is a Major Determinant of Bone Mineral Density in Men
Keywords:BMD, Cytokines, DHT.
AbstractIn the present investigation, 100 osteoporotic men with 100 age-matched normal were studied for serum sex steroids, parathyroid hormone (PTH), thyroid hormone (T3), cytokines and bone turnover markers. Serum dihydrotestosterone (DHT) was significantly decreased in osteoporotic men compared with normal. In osteoporotic men, there was a significant increase in serum interleukin (IL)-lalpha. A marked increase in bone formation marker, serum osteocalcin (OCN) and bone resorption marker, serum tartrate-resistant acid phosphatase (TRAP) reflects high bone turnover in osteoporotic men. In conclusion, the present findings point out an important role of DHT in maintaining BMD in men. A strong positive correlation of serum DHT with BMD offers new perspectives in understanding the role of non-aromatizable androgen in the regulation of bone metabolism in men.
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How to Cite
llangovan, R., Balaganesh, M., Sittadjody, S., Sivakumar, R., Sridhar, M., Vignesh, R. C., Ravi Sankar, B., Arunakaran, J., Balasubramanian, K., Michael Aruldhas, M., & Srinivasan, N. (2006). Serum Dihydrotestosterone is a Major Determinant of Bone Mineral Density in Men. Journal of Endocrinology and Reproduction, 10(1), 56–58. Retrieved from https://www.informaticsjournals.com/index.php/jer/article/view/6101