The Biology of Leydig Cell Development

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Authors

  • Center for Biomedical Research, Population Council, New York, NY 10021 ,US
  • Center for Biomedical Research, Population Council, New York, NY 10021 ,US
  • Center for Biomedical Research, Population Council, New York, NY 10021 ,US
  • Center for Biomedical Research, Population Council, New York, NY 10021 ,US
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine Auburn University, 109 Greene, Hall, Auburn, AL 36849 ,US
  • Center for Biomedical Research, Population Council, New York, NY 10021 ,US

Keywords:

Androgen Deficiency, Leydig Cell, Stem Cell, Steroidogenesis.

Abstract

Greater understanding of the growth factor regulation of Leydig cells during their postnatal differentiation has been achieved. Increasingly, attention will shift toward the goal of isolating Leydig stem cells because of their therapeutic potential in the treatment of male hypogonadism and the syndrome of androgen deficiency of aging males (ADAM). Markers of Leydig stem cells such as Kit receptor can be exploited in harvesting enriched fractions from the testis for amplification in vitro. When subsequently implanted back into the same testis, we expect the amplified stem cells to undergo differentiation into steroidogenic Leydig cells.

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Published

2004-12-01

How to Cite

Ge, R., Dong, Q., Sottas, C., Enmeiniu, ., Akingbemi, B. T., & Hardy, M. P. (2004). The Biology of Leydig Cell Development. Journal of Endocrinology and Reproduction, 8(1&2), 13–26. Retrieved from https://www.informaticsjournals.com/index.php/jer/article/view/4524