Circadian Perturbations in Immune Cell Trafficking

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  • Chronobiology and Metabolic Endocrinology Lab, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat ,IN
  • Chronobiology and Metabolic Endocrinology Lab, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat ,IN
  • Chronobiology and Metabolic Endocrinology Lab, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat ,IN
  • Chronobiology and Metabolic Endocrinology Lab, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat ,IN
  • Chronobiology and Metabolic Endocrinology Lab, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat ,IN



Circadian, Chemokines, Chrodisruption, Monocyte Homing


Immune cells form the first line of defence and are important for their properties like pathogen clearance, phagocytosis, inflammation, and tissue remodeling. Innate and adaptive immunity together work in synchrony to regulate several pro- and anti-inflammatory processes. Detection of multiple clues is the key during immune cell migration wherein: the chemokines (chemo-attractant cytokines) are extensively investigated to decipher the intricacies of migration and homing. Chemokine receptors (CXCR4, CCR2, CXCR7, etc.) expressed by the immune cells are sensitive to their ligands (CXCL12, CCL2, CXCL13, etc.) released from the site of infection. On the other hand, the circadian control of innate and adaptive immune responses is widely reported in which a state of chronodisruption hampers the organ/tissue-specific homing of immune cells. The same can affect the physiological outcome of therapeutic intervention and, hence, a profound understanding of circadian circuits controlling immune cell trafficking can provide a better understanding of disease progression and planning the course of therapy. Skewed immune cell trafficking can vary extensively as per the disease wherein the role of chronodisruption can be crucial. This review focuses on factors regulating immune cell migration and the aberrations caused due to circadian perturbations.


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How to Cite

Karnik, R., Vohra, A., Khatri, M., Dalvi, N., & Devkar, R. (2023). Circadian Perturbations in Immune Cell Trafficking. Journal of Endocrinology and Reproduction, 26(4), 213–220.



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