Progestin as an Inhibitor of Premature Ovulation through LH Suppression in IVF


  • Department of Zoology, Dinabandhu Andrews College, Kolkata - 700084, West Bengal
  • Department of Zoology, Dinabandhu Andrews College, Kolkata - 700084, West Bengal
  • Department of Zoology, Dinabandhu Andrews College, Kolkata - 700084, West Bengal



GnRH Analogue, IVF, Progestin, PPOS


Progestin is a synthetic form of progesterone hormone. Progestin is used as a contraceptive pill. Progestin can suppress
endogenous Luteinizing Hormone (LH) secretion from the pituitary. Premature ovulation in Assisted Reproductive
Technology (ART)can be prevented by taking progestin. Progestin–Primed Ovarian Stimulation (PPOS) is now widely used
for the treatment of infertility through IVF. Progestin pills are more effective than GnRH analogue for patients. Progestins
are an excellent alternative to antagonists. PPOS is slightly more advantageous than the Controlled Ovarian Stimulation
(COS) protocol. Progesterone regulates follicular growth through PI3K/AKT and MAPK signaling pathway.


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How to Cite

Das, J., Bindhani, B., & Maity, S. (2022). Progestin as an Inhibitor of Premature Ovulation through LH Suppression in IVF. Journal of Endocrinology and Reproduction, 26(3), 153–161.



Review Article