Four insecticides each in three concentrations i.e., carbaryl and malathion (0.05, 0.07 and 0.10%) and endosulfan and phosalone (0.02, 0.04 and 0.05%) were evaluated in the laboratory for their efficacy against the tobacco caterpillar, Spodoptera litura (F) simultaneous to safety considerations to the associated parasite. Aponteles sp. (vitripennis sp. group). All the insecticides proved significantly toxic to the parasite as well as to its host at all concentrations. Considering the relative safety in terms of percentage mortality inflicted to the parasite, phosalone proved to be distinctly safer of the four insecticides. Considering the maximum safety to the parasite and control of the pest, it was concluded that phosalone (0.05%) was the best.