Association of Prebiotic and Probiotic Food Consumption with Depression, Anxiety and Stress among College Going Students

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Authors

  • Manjula Suri
     Department of Physiology and Promotive Health, University of Delhi, Institute of Home Economics, Delhi ,IN
  • Vandana Sabharwal
     Department of Food and Nutrition, University of Delhi, Institute of Home Economics, Delhi ,IN
  • Pragya Kaushik
     Department of Microbiology, University of Delhi, Institute of Home Economics, Delhi ,IN
  • Anushka Joshi
     Department of Microbiology, University of Delhi, Institute of Home Economics, Delhi ,IN
  • Aayushi
     Department of Microbiology, University of Delhi, Institute of Home Economics, Delhi ,IN
  • Sunita Aggarwal
     Department of Microbiology, University of Delhi, Institute of Home Economics, Delhi ,IN

DOI:

https://doi.org/10.21048/IJND.2022.59.1.28714

Keywords:

Probiotics, prebiotics, depression, anxiety, stress, mental health, gut microbiota
Diet and mental health

Abstract

Adolescents are more susceptible to mental health conditions due to multiple physical, emotional and social changes occurring during this phase. The prevalence of depression, stress and anxiety is rising at an alarming rate in adolescents. Dietary intake has the potential to affect the mental state of an individual which is largely dependent on gut microflora composition. The study thus aims to find the influence of prebiotic and probiotic intake on mental disorders among students. A cross-sectional exploratory study was conducted among 404 college students from India. Data has been collected using convenience sampling and an online structured Google Questionnaire Form. DASS-42 questionnaire was used for collecting information on levels of depression, anxiety and stress and a validated qualitative food frequency questionnaire consisting of 13 food groups with 39 unique food items was used for understanding consumption patterns of prebiotic / probiotic foods. The findings revealed the prevalence of depression, anxiety and stress to be 56.7%, 64.1% and 52% respectively. Consumption of probiotic foods was low except for milk/milk products, vegetables, fruits, wheat / wheat products, biscuits, chocolate and methai. Yogurt and pickles were consumed frequently whereas consumption of miso paste, tausi and yakult were low. Lower consumption of a few prebiotic and probiotic foods was negatively associated with depression, anxiety and stress. This study underlines the beneficial impact of consuming prebiotic and probiotic food on mental health of college going students. Future studies are needed to generate robust evidence for advocating consumption of prebiotic and probiotic food as a preventive and therapeutic measure for promoting mental health.

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Published

2022-02-15

How to Cite

Suri, M., Sabharwal, V., Kaushik, P., Joshi, A., Aayushi, & Aggarwal, S. (2022). Association of Prebiotic and Probiotic Food Consumption with Depression, Anxiety and Stress among College Going Students. The Indian Journal of Nutrition and Dietetics, 59(1), 68–88. https://doi.org/10.21048/IJND.2022.59.1.28714

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Volume 59, Issue 1, January-March 2022

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Received 2021-09-30
Accepted 2022-01-03
Published 2022-02-15

 

References

Adolescent mental health. (n.d.). WHO.Int. Retrieved September 20, 2021, from https://www.who.int/news-room/fact-sheets/detail/adolescent-mental-health

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Lulu.com, 2020.

Cohen, S., Kessler, R.C. and Underwood Gordon, L.G. (Eds.). Measuring stress: A guide for health and social scientists. Oxford University Press, 1995.

Savitz, D.A., Danilack, V.A., Elston, B. and Lipkind, H. S. Pregnancy-induced hypertension and diabetes and the risk of cardiovascular disease, stroke and diabetes hospitalization in the year following delivery. Am. J. Epidemiol., 2014, 180, 41-44. DOI: https://doi.org/10.1093/aje/kwu118

Pellegrino, L.D., Peters, M.E., Lyketsos, C.G. and Marano, C.M. Depression in cognitive impairment. Curr. Psyc. Rep., 2013, 15, 384. DOI: https://doi.org/10.1007/s11920-013-0384-1

Walker, E.R., McGee, R.E. and Druss, B.G. Mortality in mental disorders and global disease burden implications: A systematic review and meta-analysis: A systematic review and meta-analysis. JAMA Psychiatry (Chicago, Ill.), 2015, 72, 334-341. DOI: https://doi.org/10.1001/jamapsychiatry.2014.2502

Westfall, S. and Pasinetti, G.M. The gut microbiota links dietary polyphenols with management of psychiatric mood disorders. Frontiers in Neurosci., 2019, 13, 1196. DOI: https://doi.org/10.3389/fnins.2019.01196

Holscher, H.D. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, 2017, 8, 172-184. DOI: https://doi.org/10.1080/19490976.2017.1290756

de Vrese, M. and Schrezenmeir, J. Probiotics, prebiotics, and synbiotics. Adv. Biochem. Engin. Biotechnol., 2008, 111, 1-66. DOI: https://doi.org/10.1007/10_2008_097

Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E. and Wakefield, S. Gut microbiota’s effect on mental health: The gut-brain axis. Clin. Prac., 2017, 7, 987. DOI: https://doi.org/10.4081/cp.2017.987

Taylor, A.M., Thompson, S.V., Edwards, C.G., Musaad, S.M.A., Khan, N.A. and Holscher, H. D. Associations among diet, the gastrointestinal microbiota, and negative emotional states in adults. Nutr. Neurosci., 2020, 23, 983-992. DOI: https://doi.org/10.1080/1028415X.2019.1582578

Wang, S., Xiao, Y., Tian, F., Zhao, J., Zhang, H., Zhai, Q. and Chen, W. Rational use of prebiotics for gut microbiota alterations: Specific bacterial phylotypes and related mechanisms. J. Func. Fds., 2020, 66, 103838. DOI: https://doi.org/10.1016/j.jff.2020.103838

Noonan, S., Zaveri, M., Macaninch, E. and Martyn, K. Food and mood: A review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adults. BMJ Nutr. Prev. Heal., 2020, 3, 351-362. DOI: https://doi.org/10.1136/bmjnph-2019-000053

Gibson, G.R., Scott, K.P., Rastall, R.A., Tuohy, K.M., Hotchkiss, A., Dubert-Ferrandon, A., Gareau, M., Murphy, E. F., Saulnier, D., Loh, G., Macfarlane, S., Delzenne, N., Ringel, Y., Kozianowski, G., Dickmann, R., Lenoir-Wijnkoop, I., Walker, C. and Buddington, R. Dietary prebiotics: Current status and new definition. Fd. Sci. Technol. Bull., 2010, 7, 1-19. DOI: https://doi.org/10.1616/1476-2137.15880

Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A. and Ghasemi, Y. Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Fds (Basel, Switzerland)., 2019, 8, 92. DOI: https://doi.org/10.3390/foods8030092

Report of a Joint FAO/WHO Working Group on. (n.d.). Guidelines for the evaluation of probiotics in food. Who. Int. Retrieved September 20, 2021, from https://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf

Yong, S.J., Tong, T., Chew, J. and Lim, W.L. Antidepressive mechanisms of probiotics and their therapeutic potential. Frontiers in Neurosci., 2019, 13, 1361. DOI: https://doi.org/10.3389/fnins.2019.01361

Luan, H., Wang, X. and Cai, Z. Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders. Mass Spectrom. Rev., 2019, 38, 22-33. DOI: https://doi.org/10.1002/mas.21553

Grenham, S., Clarke, G., Cryan, J.F. and Dinan, T.G. Brain-gut-microbe communication in health and disease. Frontiers in Physiol., 2011, 2, 94. DOI: https://doi.org/10.3389/fphys.2011.00094

Sarkar, A., Lehto, S.M., Harty, S., Dinan, T.G., Cryan, J.F. and Burnet, P.W.J. Psychobiotics and the manipulation of bacteria-gut-brain signals. Trds. Neurosci., 2016, 39, 763-781. DOI: https://doi.org/10.1016/j.tins.2016.09.002

Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G. and Cryan, J. F. The microbiome: Stress, health and disease. Mammalian Genome: Official J. Int. Mammalian Genome Soc., 2014, 25, 49-74. DOI: https://doi.org/10.1007/s00335-013-9488-5

Cryan, J. F. and Dinan, T. G. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Rev. Neurosci., 2012, 13, 701-712. DOI: https://doi.org/10.1038/nrn3346

Lyte, M. Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. Bio Essays: News. Rev. Molec. Cell. Develop. Biol., 2011, 33, 574-581. DOI: https://doi.org/10.1002/bies.201100024

Takada, M., Nishida, K., Kataoka-Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., Kuwano, Y., Miyazaki, K. and Rokutan, K. Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models. Neurogastroenterology and Motility: The Official J. Eur. Gastrointes. Motili. Soc., 2016, 28, 1027-1036. DOI: https://doi.org/10.1111/nmo.12804

Oleskin, A., Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia, Zhilenkova, O., Shenderov, B., Amerhanova, A., Kudrin, V. and Klodt, P. Lactic-acid bacteria supplement fermented dairy products with human behavior-modifying neuroactive compounds. J. Pharm. Nutr. Sci., 2014, 4, 199-206. DOI: https://doi.org/10.6000/1927-5951.2014.04.03.5

Pytka, K., Dziubina, A., M?yniec, K., Dziedziczak, A., ?mudzka, E., Furga?a, A., Olczyk, A., Sapa, J. and Filipek, B. The role of glutamatergic, GABAergic and cholinergic receptors in depression and antidepressant-like effect. Pharmacol. Rep., 2016, 68, 443-450. DOI: https://doi.org/10.1016/j.pharep.2015.10.006

Zhao, Z.-X., Fu, J., Ma, S.-R., Peng, R., Yu, J.-B., Cong, L., Pan, L.-B., Zhang, Z.-G., Tian, H., Che, C.-T., Wang, Y. and Jiang, J.-D. Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin. Theranost., 2018, 8, 5945-5959. DOI: https://doi.org/10.7150/thno.28068

Sun, J., Wang, F., Hong, G., Pang, M., Xu, H., Li, H., Tian, F., Fang, R., Yao, Y. and Liu, J. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neurosci. Letters, 2016, 618, 159-166. DOI: https://doi.org/10.1016/j.neulet.2016.03.003

Tabrizi, A., Khalili, L., Homayouni-Rad, A., Pourjafar, H., Dehghan, P. and Ansari, F. (). Psychobiotics, as promising functional food to patients with psychological disorders: A review on mood disorders, sleep and cognition. Neuro Quantology: An Interdis. J. Neurosci. Quantum Phy., 2019, 17. https://doi.org/10.14704/nq.2019.17.6.2189 DOI: https://doi.org/10.14704/nq.2019.17.6.2189

Lovibond, P.F. and Lovibond, S.H. The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy, 1995, 33, 335-343. DOI: https://doi.org/10.1016/0005-7967(94)00075-U

Bayaga, C.L.T., Pico, M.B., Bongga, D.C., Barrios, E.B. and Gabriel, A. A. (n.d.). Development and evaluation of a culturally sensitive food frequency questionnaire for the assessment of prebiotic and probiotic intake of urban-living, low-to-medium-income women. Gov.Ph. Retrieved September 20, 2021, from https://philjournalsci.dost.gov.ph/images/pdf/pjs_pdf/vol148no3/development_and_evaluation_of_culturally_sensitive_food_.pdf

All India Survey in Higher Education 2019-20. (n.d.). Gov.In. Retrieved September 20, 2021, from https://www.education.gov.in/sites/upload_files/mhrd/files/statistics-new/aishe_eng.pdf

Venkatarao, E., Iqbal, S. and Gupta, S. Stress, anxiety and depression among medical undergraduate students and their socio-demographic correlates. The Ind. J. Med. Res., 2015, 141, 354. DOI: https://doi.org/10.4103/0971-5916.156571

Grover, S., Raju, V.V., Sharma, A. and Shah, R. Depression in Children and Adolescents: A Review of Indian studies. Ind. J. Psychol. Med., 2019, 141, 216-227. DOI: https://doi.org/10.4103/IJPSYM.IJPSYM_5_19

Asif, S., Mudassar, A., Shahzad, T.Z., Raouf, M. and Pervaiz, T. Frequency of depression, anxiety and stress among university students. Pak. J. Med. Sci., 2020, 36, 971-976. DOI: https://doi.org/10.12669/pjms.36.5.1873

Atkinson, S.R. Elevated psychological distress in undergraduate and graduate entry students entering first year medical school. PloS One, 2020, 15, e0237008. DOI: https://doi.org/10.1371/journal.pone.0237008

Vecchio, M.G., Paramesh, E.C., Paramesh, H., Loganes, C., Ballali, S., Gafare, C.E., Verduci, E. and Gulati, A. Types of food and nutrient intake in India: A literature review. Ind. J. Pediat., 2014, 81, 17-22. DOI: https://doi.org/10.1007/s12098-014-1465-9

Subramanyam, M.A., Kawachi, I., Berkman, L.F. and Subramanian, S.V. Socioeconomic inequalities in childhood under nutrition in India: analyzing trends between 1992 and 2005. PloS One, 2010, 5, e11392. DOI: https://doi.org/10.1371/journal.pone.0011392

Rana, R. (n.d.). Processing Quality Potatoes in India: An Analysis of Industry’s demand. Researchgate.Net. Retrieved September 20, 2021, from https://www.researchgate.net/publication/202300338_Processing_Quality_Potatoes_in_India_An_Analysis_of_Industry’s_Demand

(2021, July 10). Instantnoodles.org. http://instantnoodles.org/noodles/expanding-market.html

Diaz Heijtz, R., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M.L., Forssberg, H. and Pettersson, S. Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 3047-3052. DOI: https://doi.org/10.1073/pnas.1010529108

Chu, C., Murdock, M.H., Jing, D., Won, T.H., Chung, H., Kressel, A.M., Tsaava, T., Addorisio, M.E., Putzel, G.G., Zhou, L., Bessman, N. J., Yang, R., Moriyama, S., Parkhurst, C.N., Li, A., Meyer, H.C., Teng, F., Chavan, S.S., Tracey, K.J. and Artis, D. The microbiotas regulate neuronal function and fear extinction learning. Nature, 2019, 574, 543-548. DOI: https://doi.org/10.1038/s41586-019-1644-y

Kim, C.S. and Shin, D.M. Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study. Nutr. (Burbank, Los Angeles County, Calif.), 2019, 63, 169-174. DOI: https://doi.org/10.1016/j.nut.2019.02.007

PT739. Rice is nice: benefits of rice consumption for brain health. The Int. J. Neuropsychopharmacol., 2016, 19, 69-69. DOI: https://doi.org/10.1093/ijnp/pyw044.739

Neyrinck, A.M., Van Hée, V.F., Piront, N., De Backer, F., Toussaint, O., Cani, P.D. and Delzenne, N. M. Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice. Nutr. Diabet., 2012, 2, e28. DOI: https://doi.org/10.1038/nutd.2011.24

Cao, D., Li, H., Yi, J., Zhang, J., Che, H., Cao, J., Yang, L., Zhu, C. and Jiang, W. Antioxidant properties of the mung bean flavonoids on alleviating heat stress. PloS One, 2011, 6, e21071. DOI: https://doi.org/10.1371/journal.pone.0021071

Keunen, K., van Elburg, R.M., van Bel, F. and Benders, M.J.N.L. Impact of nutrition on brain development and its neuroprotective implications following preterm birth. Pediat. Res., 2015, 77, 148-155. DOI: https://doi.org/10.1038/pr.2014.171

Su, Q., Yu, B., He, H., Zhang, Q., Meng, G., Wu, H., Du, H., Liu, L., Shi, H., Xia, Y., Guo, X., Liu, X., Li, C., Bao, X., Gu, Y., Fang, L., Yu, F., Yang, H., Sun, S. and Niu, K. Nut consumption is associated with depressive symptoms among Chinese adults: Research article: Nut consumption and depressive symptoms. Depress. Anxiety, 2016, 33, 1065-1072. DOI: https://doi.org/10.1002/da.22516

Anjom-Shoae, J., Sadeghi, O., Keshteli, A.H., Afshar, H., Esmaillzadeh, A. and Adibi, P. Legume and nut consumption in relation to depression, anxiety and psychological distress in Iranian adults. Eur. J. Nutr., 2020, 59, 3635-3645. DOI: https://doi.org/10.1007/s00394-020-02197-1

Hilimire, M.R., DeVylder, J.E. and Forestell, C.A. Fermented foods, neuroticism and social anxiety: An interaction model. Psyc. Res., 2015, 228, 203-208. DOI: https://doi.org/10.1016/j.psychres.2015.04.023

Perez-Cornago, A., Sanchez-Villegas, A., Bes-Rastrollo, M., Gea, A., Molero, P., Lahortiga-Ramos, F. and Martínez-González, M.A. Intake of high-fat yogurt, but not of low-fat yogurt or prebiotics, is related to lower risk of depression in women of the SUN cohort study. The J. Nutr., 2016, 146, 1731-1739. DOI: https://doi.org/10.3945/jn.116.233858

Pepeu, G. and Giovannini, M.G. Cholinesterase inhibitors and memory. Chemico-Biological Interactions, 2010, 187, 403-408. DOI: https://doi.org/10.1016/j.cbi.2009.11.018

Rao, A.V., Bested, A.C., Beaulne, T.M., Katzman, M.A., Iorio, C., Berardi, J.M., and Logan, A.C. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathogens, 2009, 1, 6. DOI: https://doi.org/10.1186/1757-4749-1-6

Nikolova, V., Zaidi, S.Y., Young, A.H., Cleare, A.J. and Stone, J.M. Gut feeling: Randomized controlled trials of probiotics for the treatment of clinical depression: Systematic review and meta-analysis. Therapeutic Adv. Psychopharmacol., 2019, 9, 2045125319859963. DOI: https://doi.org/10.1177/2045125319859963

Miyaoka, T., Kanayama, M., Wake, R., Hashioka, S., Hayashida, M., Nagahama, M., Okazaki, S., Yamashita, S., Miura, S., Miki, H., Matsuda, H., Koike, M., Izuhara, M., Araki, T., Tsuchie, K., Azis, I.A., Arauchi, R., Abdullah, R.A., Oh-Nishi, A. and Horiguchi, J. Clostridium butyricum MIYAIRI 588 as adjunctive therapy for treatment-resistant major depressive disorder: A prospective open-label trial: A prospective open-label trial. Clin. Neuropharmacol., 2018, 41, 151-155. DOI: https://doi.org/10.1097/WNF.0000000000000299

Rudzki, L., Ostrowska, L., Pawlak, D., Ma?us, A., Pawlak, K., Waszkiewicz, N, and Szulc, A. Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study. Psycho neuro endocrinol., 2019, 100, 213-222. DOI: https://doi.org/10.1016/j.psyneuen.2018.10.010