Do Nutritional and Inflammatory Biomarkers Have Prognostic Significance in the Early Post Operative Period in Head and Neck Cancer? – A Pilot Study

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Authors

  • Nikhila Sham Sunder Bharadwaj
     Department of Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore - 560 027 ,IN ORCID logo http://orcid.org/0000-0002-2854-2720
  • Ravi Nayar
     Dean, Centre for Academic Research, Otolaryngology Skills and Expertise, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore - 560 027 ,IN
  • Vishal Rao
     Consultant, Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore - 560 027 ,IN
  • Mehnanaz Fathima
     Department of Nutrition, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore - 560 027 ,IN
  • Afrose Parveen
     Head of Dietetics and Nutrition, Department of Nutrition, Center for Academic Research, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore - 560 027 ,IN

DOI:

https://doi.org/10.21048/ijnd.2018.55.1.16346

Keywords:

Prognostic significance, inflammatory parameters, wound infection (WI) rates, pathological diagnosis, Nutritional Risk Index (NRI)

Abstract

This pilot study evaluated prognostic significance of patient/tumor factors and nutritional/inflammatory parameters with respect to the early post operative complications such as Wound Infection (WI) rates and Length of Hospital Stay (LOS) in 26 Head and Neck Cancer (HNC) surgical patients. The prognostic indices were calculated using patient and tumor related variables including age, sex, co-morbidity, tobacco usage, pathological diagnosis, hemoglobin (Hb) and albumin. The WI rate in the present study was found to be 30% and significantly correlated with both tobacco usage (p=0.021) and nutritional indices such as Albumin/ Globulin ratio (A/G) (p = 0.034) and Nutritional Risk Index (NRI) (p = 0.043). LOS (9.32 ± 2.719) was significantly correlated to Albumin levels (p = 0.002), A/G ratio (p = 0.02) and Prognostic Nutritional Index (PNI) (p = 0.006) and NRI (p = 0.002). This pilot study suggested that a positive history of tobacco usage and immune nutritional factors may influence early post-operative outcomes in head and neck surgery.

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Published

2018-01-12

How to Cite

Sunder Bharadwaj, N. S., Nayar, R., Rao, V., Fathima, M., & Parveen, A. (2018). Do Nutritional and Inflammatory Biomarkers Have Prognostic Significance in the Early Post Operative Period in Head and Neck Cancer? – A Pilot Study. The Indian Journal of Nutrition and Dietetics, 55(1), 79–87. https://doi.org/10.21048/ijnd.2018.55.1.16346

Issue

Volume 55, Issue 1, January - March 2018

Section

Original Articles

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Europe PMC
Received 2017-06-28
Accepted 2017-10-25
Published 2018-01-12

 

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