A Gross Comparative Anatomical Study of Hearts in Human Cadavers and Pigs


Affiliations

  • Pt. Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India
  • DMCH, Ludhiana, India
  • LPS Institute of Cardiology GSVM Medical College, Kanpur, India

Abstract

The inadequate availability of human donor hearts and other organs has inspired interest in field of xenotransplantation. The prospect of transgenic pig providing compatible organs for human xenotransplantation is becoming more likely. We aim to compare cardiac anatomy of pig hearts with human cadaveric hearts. A comparative analysis of pig and human cardiac anatomy was made by gross examination and dissection of hearts. The mean value of various parameters along with standard deviation was calculated.and T-test was applied and p-value was calculated. The average weight of human heart was 266.5g whereas the average weight of pig heart was 302.8g. An average adult human heart was about 9.8cm (9.2cm-12cm) from base to apex, 8.6 cm (7.4cm-10.8cm) in its broadest transverse diameter and 7.1 cm (5cm-8.4cm) anteroposteriorly. An average pig heart was about 10.2 cm (8.5cm-11cm) from base to apex, 8.9 cm (6.5cm-11cm) in its broadest transverse diameter and 6.6 cm (5cm- 8cm) anteroposteriorly. The human heart was trapezoidal in shape. The pig heart, in contrast, was a broad cone shaped organ. In humans, the left atrium received the four pulmonary veins whereas in pig it received two pulmonary veins. In right atrium of man, orifices of superior and inferior caval veins were in a direct line whereas in pig veins opened at right angles to each other.

The present study suggests that the morphology of human and porcine heart is almost similar with significant anatomical differences between porcine and human hearts that might effect the success of the cardiac xenograft within the human recipient.


Keywords

Cardiac Anatomy, Xenotransplantation, Xenograft.

Subject Discipline

Cardiology

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References

Axel Kornerup Hansen, Kirsten Dahl and Dorte Bratbo Sorensen. Rearing and Caring for a Future Xenograft Donor Pig. Acta Vet Scand 2002; Suppl 99:45-50.

Jatene MB, Monteiro R, Guimaraes, MH, Veronezi SC, Koike MK, Jatene FB, et al. Aortic valve assessment. Anatomical study of 100 healthy human hearts. Arq Bras Cardiol 1999;73(1): 81-6.

Arora V. Histopathological studies of coronary arteries in cases of unnatural deaths. [Thesis MD]. Amritsar: Baba Farid University of Health Sciences; 2003.

Johnson D. Heart. In Standring S, Ellis H, Healy JC, Johnson D, Williams A, Collins P, et al editors. Gray’s Anatomy. The Anatomical Basis of Clinical Practice. 39th ed. London: Elsevier Churchill Livingstone; 2005. .p.995-1027.

Monica Garg, Akash Deep Agarwal, Sant Prakash Kataria Coronary Atherosclerosis and Myocardial infarction An Autopsy Study. J Indian Acad Forensic Med Jan-Mar 2011; 33(1):39-42.

Dhruva GA, Agravat AH, Sanghvi HK. Atherosclerosis of Coronary Arteries as predisposing factor in Myocardial Infarction: An Autopsy Study. Online J Health Allied Scs 2012;11(3):1. Available at URL: http://www.ojhas.org/issue43/2012 -3-1.htm

Dyce KM, Sack WO, Klensing CJG. Text Book of Veterinary Anatomy. 3 rd edition. Philadelphia: WB Saunders Company; 1975.p.554-618.

Crick SG, Sheppard MN, Ho SY, Gebhtein L, Anderson RH. Anatomy of pig heart: comparisons with normal human cardiac structure. J Anat 1998;193:105-19.

Cabrol C, Gandjbakhch I, Pavie A, Bors V, Dalous P, Baud F et al. Surgical procedure. In Wallwork J, editors. Heart and Heart-Lung Transplantation. Philadelphia: W.B. Saunders 1989; p.119- 43.

Anderson RH, Becker AE. In The Heart: Structure in Health and Disease London: Gower Medical; 1992.p.1-40.

Uemura H, Anderson RH, Ho SY, Devine WA, Neches WH, Smith A et al. Left ventricular structures in atrioventricular septal defect associated with isomerism of atrial appendages compared with similar features with usual atrial arrangement. J Thorac Cardiovasc Surg 1995;110:444-52.


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