Cytological Study of Palpable Breast Lumps with their Histological Correlation
Objectives: To evaluate role of fine needle aspiration cytology in the diagnosis of breast lesions and to compare the cytological findings with the histopathology wherever possible. In addition the sensitivity, specificity and accuracy of FNAC in breast lesions are carried out.
Material and Methods: The present study was carried out on 200 patients who presented with palpable lump in the breast in the Department of Pathology, Government Medical College, Patiala over a period of 2 years. Cytological Diagnosis was correlated with histological findings wherever possible.
Results: Cytologically, the lesions were categorized into 4 major categories, benign 143 (71.5%), malignant 37 (18.5%), suspicious or atypical 10 (5%) and unsatisfactory 10 (5%). Out of these 200 cases, 85 cases (42.5%) were available for histopathological examination. The most common benign lesion in this study was fibroadenoma 23/52 (44.2%) and the most common malignant lesion was infiltrating ductal carcinoma (28/33) Diagnostic accuracy of FNAC for benign lesion was 94.2% while for malignant lesion, it was 96.7%. The sensitivity, specificity and overall diagnostic accuracy of FNAC came out to be 93.7%, 98.1% and 96.4% respectively.
Conclusion: FNAC is a simple and reliable method for diagnosis of both benign and malignant lesions quite accurately thus reducing unnecessary surgeries. The present study proved that the procedure has high sensitivity, specificity and diagnostic accuracy. Though it cannot categorize the lesion in some cases but it can rule out malignancy in most of the cases. Considering its low cost and quick results, it can be a potential tool for screening of breast cancers.
Rosenthal DL. Breast lesions diagnosed by FNAC. Pathol Res Prac 1986; 181:1351-1357.
Lamb J, Anderson TJ, Dixon MJ, Levack PA. Role of fine needle aspiration cytology in breast cancer screening. Journal of Clinical pathology 1987;40: 705-709.
Bal MS, Bidani R, Kahlon S.Comparative evaluation of aspiration cytology and preoperative imprint cytology in breast lesions. Journal of Cytology 2000;17(1):27-32.
Park K. Screening for disease. In Parkâ€™s textbook of Preventive and Social Medicine. 21st ed. Jabalpur: Bhanot publishers; 2011.p.116-118.
Rubin M, Horiuchi K, Joy N, Huah W, Read R, Ratzer E, et al. Use of fine needle aspiration for solid breast lesions is accurate and cost-effective, American Journal of Surgery 1997; 174(6):694â€“698.
Berner A, Sigstad E, Reed W, Risberg B. Fine-needle aspiration cytology or core biopsy when diagnosing tumours of the breast. Tidsskrift for den Norske Laegeforening 2003;123(12):1677â€“ 1679.
Lieu D. Value of cytopathologistperformed ultrasound-guided fineneedle aspiration as a screening test for ultrasound-guided core-needle biopsy in non-palpable breast masses. Diagnostic Cytopathology 2009:37(4):262â€“269.
Lannin DR, Silverman JF, Walker C, Pories WJ. Cost-effectiveness of fine needle biopsy of the breast. Annals of Surgery 1986;203(5):474â€“480.
Lau SK, McKee GT, Weir MM, Tambouret RH, Eichhorn JH, Pitman MB. The negative predicative value of breast fine-needle aspiration biopsy: the massachusetts general hospital experience. Breast Journal 2004; 10(6):487â€“491.
Park IA & Ham EK. FNAC of palpable breast lesions. Acta Cytologica 1997; 41(4):1131-1138.
Choi Y.D. Choi Y.H. Lee J. Nam J.H. Ju hng S. Choi C. Analysis of FNAC of breast. Acta Cytologica 2004;48(6): 801-806.
Hammond S, Keyhan I, Rofagha S. Statistical analysis of fine needle aspiration cytology of breast: A review of 678 cases plus 4265 cases from literature. Acta Cytologica 1987; 31:276-280.
Watson DP, McGurie M, Nicholson F, Given HF. Aspiration cytology and its relevance to the diagnosis of solid tumors of breast. Surg Gynaeco obstet 1987;165:435-441.
Nicosia SV, Williams JA, Horowitz SA, Ku NN, Shabaik AS, Mela N, et al. FNAB of palpable breast lesions: Review and statistical analysis of 1875 cases. Surgical Oncol 1993;2(3):145160.
- There are currently no refbacks.