Preparation, Characterization and Evaluation of Hepatoprotective Activity of NNDMAC Biodegradable Parenteral Sustained Release Microspheres


  • Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, 506001, India
  • Vaagdevi College of Pharmacy, Research and PG Studies, Warangal, Andhra Pradesh, 506001, Oman


The objective of this work was to prepare biodegradable sustaine d release parenteral microspheres of NNDMA-curcumin (NNDMAC), a novel curcumin analogue , characterize the formulation and evaluate the hepatoprotective activity of the microsphere formulation. Microspheres were prepared using solvent evaporation technique usin g polycaprolactone and were further characterized for various parameters. In vivo animal studies for 10 days were carried out for the determination of hepatoprotective activity of the formul ation in a CCl 4 model. Particles of 12 μm size with 75.41% yield with no drug-polymer interaction were obtai ned. The drug release was sustained for 10 days. Significant hepatoprotect ion which was better than repeated I.V. administration was offered by the microsphere fo rmulation in this 10-day study. Prepared NNDMAC microspheres have potential use in liver toxicity/ cirrhosis.


NNDMAC, Microspheres, In Vitro Release, Biodegradable Polymer, Hepatoprotection.

Subject Discipline

Pharmacy and Pharmacology

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Banerjee R, Das A, Ghoshal U and Sinha M, Predicting mortality in patients with cirrhosis of liver with application of neural network technology, J Gastenter. Hepat., 2003, 18: 1054-1060.

Girish, C, Pradhan, and Suresh Chandra, Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin, Fundamental and Clinical Pharmacology, 2008: 22(6); 623-632.

Ishita Chattopadhyay, Kaushik Biswas, Uday Bandyopadhyay and Ranajit K. Banerjee. Turmeric and curcumin: Biological actions and medicinal applications. Current Science, 2004, 87(1); 44-53.

Jithan Aukunuru and Chinnalalaiah Runja, Synthesis and evaluation of antidepressant activity of some curcumin-like compounds, InPharm Communique, 2009, 2(2): 38-41.

Jothirmayi Shankeshi, Jithan Aukunuru and Malla Reddy Vanga. Preclinical assissment of sustained release biodegradable curcumin microspheres in diabetes. Proc. A. P. Akademi of Sciences, Hyderabad, 2007: 11(3); 180-187.

Joythirmayi Shankeshi and Jithan Aukunuru, Preparation, characterization and evaluation of antidiabetic activity of a liposomal formulation encapsulating curcumin, an ayurvedic natural product, The Pharmacist, 2008, 3(2): 1-5.


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