Evaluation of the Powder and Compaction Properties of Microcrystalline Starch (MCS) Derived from Cassava (Manihot Esculenta Crantz) Starch by Enzymatic Hydrolysis


  • Ahmadu Bello University, Department of Pharmaceutics and Pharmaceutical Microbiology, Zaria, Kaduna, Nigeria


The aim of this study was to investigate and determine the powder and compaction properties of microcrystalline starch (MCS) and compare with the properties of a well known direct compression filler - binder, microcrystalline cellulose (MCC).

Cassava starch was extracted from the freshly harvested tubers of Manihot esculenta Crantz and subjected to 5hours of enzymatic hydrolysis to yield microcrystalline starch. The powder and compaction properties were evaluat ed and compared with MCC 101, a commercial brand of microcrystalline cellulose.

Results of the powder properties of MCS revealed differences in the particle size, angle of repose, flow rate, bulk density, tapped density, true density, Hausner's ratio, Carr 's index and powder porosity when compared to MCC. The compaction studies of both materials revealed that MCS had a faster onset of deformation and a greater extent of deformation in comparison to MCC. These results suggest that MCS has the potential of be ing used as a filler - binder in direct compression tableting.


Microcrystalline Starch (MCS), Microcrystalline Cellulose (MCC), Powder Properties, Compaction Properties, Direct Compression Tableting and Filler - Binder.

Subject Discipline

Pharmacy and Pharmacology

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Adams MJ, McKeown R, Micromechanical analyses of the pressure volume relationship for powders under confined uniaxial compression, Powder Technol, 88, 1996, 155163.

Alebiowu G, Studies on the tableting properties of Sorghum bicolour Linn (Poaceae) starch 1: Evaluation of binder types and concentrations on the properties of sorghum starch granulations, Discov Innov, 13, 2001, 73-77.

Apeji YE, Tableting properties of microcrystalline starch derived from cassava (Manihot esculenta Crantz) starch by enzymatic hydrolysis using α-amylase enzyme, M.Sc Thesis, Ahmadu Bello University, 2010.

Arora V, Gupta VB, Singhal R, Advances in direct compression technology, Pharma Times, 39, 2007, 26-27.

Banker GS, Anderson NR, The theory and practice of industrial pharmacy, 3 rd edition, Vargese Publishing House, India, 1986, 314324.

Buwalda P, Arends–Scholte AW, Use of microcrystalline starch products as tabletting excipients, International Patent (WO 97/31267), 1997.

Carlson GT, Hancock BC, Excipient development for pharmaceutical, biotechnology and drug delivery systems, 1st Edition, Informa Healthcare, New York, 2006, 127-154.

Carr RL, Evaluating flow properties of solids, Chem Eng, 72, 1965, 163-168.

Heckel RW, An analysis of powder compaction phenomena, Trans Metall Soc Aime, 221, 1961, 1001-1008.

Heckel RW, Density-Pressure relationship in powder compaction, Trans Metall Soc Aime, 221, 1961a, 671-675.

Isimi CY, Nasipuri RN, Ojile JB, Ibrahim YKE, Emeje M, Effects of the diluents type on compressional characteristics of the mixed stem bark extract of Anogeissus leiocarpus and Prosopsis africana tablet formulation, Acta Pharm, 53, 2003, 49-56.

Iwuagwu MA, Onyekweli AO, Preliminary investigation into the use of Pleurotus tuberregium powder as a tablet disintegrants, Trop J Pharm Res, 1, 2002, 29-37.

Kawakita K, Hattori I, Kishigami M, Characteristic constants in Kawakita's powder compression equation, J Powder Bulk Solids Technol, 1, 1977, 3-8.

Kawakita K, Ludde KH, Some considerations on powder compression equations, Powder Technol, 4, 1971, 61-68.

Kornblum SS, Stoopak SB, A new tablet disintegrant agent: crossslinked polyvinylpyrrolidone, J Pharm Sci, 62, 1, 1973, 43-49.

Mattsson S, Pharmaceutical binders and their function in directly compressed tablets, PhD Dissertation, Uppsala University, Sweden, 2000.

Nicklasson F, Alderborn G, (2000) Analysis of the compression mechanics of pharmaceutical agglomerates of different porosity and composition using the Adams and Kawakita equations, Pharm Res, 17, 2000, 949-954.

Odeku OA, Awe OO, Popoola B, Odeniyi MA, Itiola OA, Compression and mechanical properties of tablet formulations containing corn, sweet potato and cocoyam starches as binders, Pharm Tech, 2005, 82-90.

Odeku OA, Itiola OA, Compaction properties of three types of starch, IJPR, 6(1), 2007, 1723.

Robert RJ, Rowe RC, The effect of the relationship between punch velocity and particle size on the compaction behavior of materials with ranging deformation mechanism, J Pharm Pharmacol, 38, 1986, 567–571.

Staniforth JN, Pharmaceutics: The Science of dosage form design, 1st Edition, Churchill Livingstone Medical division of Longman group, UK, 1996, 600-615.

Wells, J.I. & Aulton, M.E. (2007) Pharmaceutical Preformulation In: M.E. Aulton, (Ed.). Aulton’s Pharmaceutics: The design and manufacture of medicines, 3rd Edition, Churchill Livingstone Elsevier, London, 2007, 336-360.

York P, Pilpel N, The tensile strength and compression behavior of lactose, four fatty acids and their mixtures in relation to tableting, J Pharm Pharmacol, 25, 1973, 1–11.


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