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Preparation and Evaluation of Niosomes of Brimonidine Tartrate as Ocular Drug Delivery System


Affiliations

  • Nitte Gulabi Shetty Memorial Institute Pharmaceutical Sciences, Mangalore, Karnataka, 574160, India

Abstract

Nioosomes of brimonidine tartrate were prepared by film hydration method. The prepared vesicles were evaluated for photomicroscopic characteristics, entrapment efficiency, in vitro, ex- in vitro drug release, in vivo intra ocular pressure lowering activity. Methods employed for the preparation of vesicles were found to be simple and reproducible, produced vesicles of acceptable shape and size with unimodal frequency distribution pattern. The in vitro, ex-in vitro drug release studies showed that there was a slow and prolonged release of drug which followed zero order kinetics. The intra ocular pressure lowering activity of prepared formulations were determined and compared with pure drug solution. It was found that intra ocular pressure lowering action was sustained for longer period of time. Stability study data revealed that the formulations were found to be stable when stored at refrigerator temperature (2 °C to 8 °C) and at 25 °C with no change in shape and drug content. Results of the study indicated that it is possible to develop a safe and physiological effective topical niosomal formulation which is patient compliance.

Keywords

Niosome, Film Hydration, Bromonidine Tartrate, Intra Ocular Pressure.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

References

Amaranth Sharma, Uma Sharma. Liposome in drug delivery: progress and limitation. Int J Pharma. 154;1997:123-40.

Sandeep KS, Meenakshi Chauhan* and b Narayanapillay Anilkumar. Span-60 niosomal oral suspension of fluconazole: Formulation and in vitro evaluation. J Pharm Res Health Care. 1(2); 2009: 142-56

Indu Pal K, Alka G, Anil K, Deepika A. Vesicular systems in ocular drug delivery: An overview. Int J Pharma. 269(1); 200: 4114.

Dong H Shin, Bernice K, Glover, Sooncha, Yong Y, Chaesik kim, Khoa D. Naguyen. Long term brimonidine therapy in glaucoma patients with apraclonidine allergy. Ame J Ophtha;.127(5); 1999:511-15.

Anuja Bhandari, George A, E Michale, Selim Orgul, Lin Wang. Effect of brimonidine on optic nerve blood flow in rabbits. Ame J Ophtha. 128(5-12);1999: 601-05.

Bangham AD, Standish MM, Watkens JC. Liposomes by film hydration technique. J C J Mol Biol. 13; 1965: 238.

Law SL, Shih CL. Characterization of calcitonin-containing liposomes formulations for intranasal delivery. J Microencapsul. 18; 2001:211-21.

Deepika Aggarwal, Alka Garg, Indupal K. Development of topical niosomal preparation of acetazolamide: preparation and evaluation. J Pharm Pharmacol. 56; 2002: 1509-17

Kaur IP, Singh M, Kanwar M. Formulation and evaluation of ophthalmic preparation of acetazolamide. Int J Pharm. 199; 2000:11927.

Armengol X, Estelrich J. Physical stability of different liposome compositions obtained by extrusion method. J Microencapsul. 12; 1995:525-535.

Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate release of solid drugs dispersed in solid matrices. j pharm sci 52; 1963: 1145-49.


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