Computational Studies of Sirtuins in the Treatment of Type II Diabetes mellitus


  • GITAM University, Department of Bioinformatics, Visakhapatnam, A. P., 530002, India


Ageing in humans refers to a biological process of life engaged with physical, psychological, and social changes. Different species of animals age at radically different paces and occurrences of diseases. D rug designing approaches related to an aging factor, Type 2 Diabetes mellitus has been reported in the present study. Resveratrol and human Sirtuins (1 to 6) are docked against Type 2 Diabetes mellitus HNF - 1a motif with PDB ID: 2GYP using Hex 5.1. Resveratrol and Sirtuin 6 shown good results and can use as anti - aging drugs against Type 2 Diabetes mellitus.


Drug Designing, Ageing, Type 2 Diabetes Mellitus, Docking.

Subject Discipline

Pharmacy and Pharmacology

Full Text:


Michael CP, Handbook of models for human aging, Academic Press, 2006, 45.

Leslie AM, Suzanne K, Ageing: The Social Context. 2nd edition, Pine Forge Press, 2007, xix.

Roberta R, Paola M, Nesrin O, Jean-Marc Z, Angelo A, Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition, Free Radical Biology and Medicine, 27(7-8), 1999, 729737.

Wayne JU, Gender, Race and the National Education Association: Professionalism and Its Limitations, Taylor & Francis, 2000, 1-4.

James EB, Mathematical Modeling and Analysis in Biochemical Engineering : Past Accomplishments and Future Opportunities, Biotechnol. Prog., 14, 1998, 8-20.

Leonard G, Cynthia K, Genetic pathways that regulate ageing in model organisms, Nature, 408, 2000, 255-262.

North BJ, Verdin E, Sirtuins: Sir2-related NADdependent protein deacetylases, Genome Biol., 5(5), 2004, 224.

Yamamoto H, Schoonjans K, Auwerx J, Sirtuin functions in health and disease, Mol. Endocrinol., 21(8), 2007, 1745–1755.

Sandra RR, Juan LFM, Agustin FF, Edelmiro MT, Mario FF, Epigenetic Regulation of Aging, Discov Med., 10(52), 2010, 225-233.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, Nature, 450(7170), 2007, 712–716.

Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y, Bonavida B, Resveratrol and Cancer: Chemoprevention, Apoptosis, and Chemoimmunosensitizing Activities, Current Medicinal Chemistry - Anti-Cancer Agents, 3(2), 2003, 77-93.

Raymond B, Olivier D, Anthocyanin molecular interactions: the first step in the formation of new pigments during wine aging?, Food Chemistry, 51(4), 1994, 365-371 13. Daisy P, Mathew S, Suveena S, Nirmala AR, A Novel Terpenoid from Elephantopus Scaber – Antibacterial Activity on Staphylococcus Aureus: A Substantiate Computational Approach, Int J Biomed Sc., 4(3), 2008, 196-203.


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