Relationship between Hypomagnesemia and Dyslipidemia in Type 2 Diabetes Mellitus


Affiliations

  • Sri Muthukumaran Medical College and Research Institute, Department of Biochemistry, Chennai, India
  • Sri Ramachandra Hospital, Central Laboratory, Chennai, India

Abstract

Magnesium is an important macro mineral in the mammalian cells. It is a cofactor for many enzymes involved in lipid metabolism like lipoprotein lipase, pyrophosphatase etc . In magnesium deficiency, these enzymes are defective and leads to dyslipidemia in type 2 diabetic patients. Objective : To observe the association between hypomagnesemia and dyslipidemia in type 2 diabetic patients. Methodology: A case control South Indian population study consist ed of control group (40 healthy individuals) and case group (203 patients who were diagnosed as type 2 diabetes). Serum magnesium and lipid profile was analyzed in blood samples using standard kits in fully automated analyzer. The data was analyzed using Student's 't' test and correlation coefficient. Result: In the present study, a significant low serum magnesium levels (p<0.01) in case group was observed when compared to control group . A significant decreased cholesterol levels (p<0.05) and serum HDL levels (p<0.001) was observed in case group when compared to control group. In case group, we found a significant increased triglycerides (p<0.05) and LDL levels (p<0.001) when compared to control group. A positive correlation was observed between magnesium and cholesterol (r = 0.195, p<0.01), magnesium and LDL (r = 0.202, p<0.01), magnesium and total cholesterol HDL ratio (r = 0.142, p<0.05) in the case gr oup. Conclusion: We observed hypomagnesemia in type 2 diabetes patients with dyslipidemia.

Keywords

Hypomagnesemia, Lipoprotein Lipase and Dyslipidemia.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

References

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