Evaluation of Phytochemicals, Antioxidant and Cytotoxic Activities of Lavandula Antineae Maire Endemic Medicinal Plant from Algeria


Affiliations

  • ENS Kouba, Laboratory of Bioactive Products and Biomass Valorization Research, Algeria
  • ENS Kouba, Department of Natural Sciences, Algeria
  • USTHB, Algiers, Algeria

Abstract

The present study was designed to investigate the phytochemical screening, t otal phenolic and flavonoid contents, antioxidant and cytotoxic a ctivities of Lavandula antineae Maire for the first time. Phytochemical screening revealed the presence of a nthraquinones, t riterpenes, s aponins, f lavonoids, t annins, O - heterosides, C - heterosides . Total p henolic and flavonoid contents of the extracts varie d between 12.49 - 262.35 mg GAE/g extract and 1 . 35 - 4 . 03 mg QE/g extract, respectively. The antioxidant activity was investigated using DPPH, reducing power and β - carotene /linoleic acid tests . The results indicated that ethyl acetate and diethyl ether fractio n s exhibited stronger activities than hydromethanolic crude extract and other fractions. In case of cytotoxicity assay, hydromethanolic extract was found to show good toxicity against brine shrimp nauplii (LC 50 = 13.72 μg/ml )

Keywords

Lavandula antineae, Antioxidant Activity , Cytotoxic Activity, Phytochemical Screening.

Subject Discipline

Pharmacy and Pharmacology

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References

Costa P, Gonçalves S, Andrade PB, Valentão P, Romanoa A. Inhibitory effect of Lavandula viridis on Fe2+-induced lipid peroxidation, antioxidant and anti-cholinesterase properties. Food Chem 2011; 126 : 1779-1786.

Gülçin Ì, Şat G, Beydemir Ş, Elmastaş M, Küfrevioǧlu Öİ. Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.). Food Chem 2004; 87: 393- 400.

Sosa S, Altinier G, Politi M, Braca A, Morelli I, Della Loggia R. Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity. Phytomedicine 2005; 12: 271-277.

González-Coloma A, Delgado F, Rodilla J M, Silva L, Sanz J, Burillo J. Chemical and biological profiles of Lavandula luisieri essential oils from western Iberia Peninsula populations. Biochem Syst Ecol 2011; 39: 1-8.

Dob T, Dahmane D, Agli M, Chelghoum C. Essential oil composition of Lavandula stoechas from Algeria. Pharm Biol 2006 ; 44: 60-64.

Upson TM, Grayer RJ, Greenham JR, Williams CA, Al-Ghamdi F, Chen F-H. Leaf flavonoids as systematic characters in the genera Lavandula and Sabaudia. Biochem Syst Ecol 2000; 28: 991-1007.

Upson TM & Jury SL. The re-circumscription and lectotypification of Lavandula antineae Maire and description of a new species L. saharica Upson & Jury (Lamiaceae). Kew Bull 2004; 58: 889-901.

Sahki A & Sahki R. Le Hoggar: Promonade Botanique. Lyon, France : Ésope-Lyon/Chamonix, 2004.

Hammiche V & Maiza K. Traditional medicine in Central Sahara: Pharmacopoeia of TassiliN’ajjer. J Ethnopharmacol 2006; 105: 358-367.

Paris R & Moyse H. Précis de matière médicale (Tome I). Paris, France: Edition Masson, 1976.

Singleton VL & Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. AM J Enol Vitic 1965; 16: 144−153.

Lamairson JLC & Carnet A. Teneurs en principaux flavonoides des fleurs de Crataegus monogyna Jacq. et de Crataegus laevigata (Poiret) DC. en fonction de la période de végétation. Pharm Acta Helv 1990 ; 65 : 315-320.

Braca A, Sortino C, Politi M, Morelli I, Mendez J. Antioxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol 2002; 79: 379-381.

Oyaizu M. Studies on products of browning reactions: antioxidant activities of products of browning reaction prepared from glucosamine. J Nutrit 1986; 44: 307-315.

Shon MY, Kim TH, Sung NJ. Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts. Food Chem 2003; 82: 593-597.

Al-Saikhan MS, Howard LR, Miller JC. Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum L.). J Food Sci 1995; 60: 341-347.

Turker AU & Camper ND. Biological activity of common mullein, a medicinal plant. J Ethnopharmacol 2002; 82: 117-125.

Da Silva ARA, de Morais SM, Mendes Marques MM, de Oliveira DF, Barros CC, de Almeida RR et al. Chemical composition, antioxidant and antibacterial activities of two Spondias species from Northeastern Brazil. Pharm Biol. 2012; 50: 740-746.

Capecka E, Mareczek A, Leja M. Antioxidant activity of fresh and dry herbs of some Lamiaceae species. Food Chem 2005; 93: 223-226.

Wong CC, Li HB, Cheng KW, Chen F. A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay. Food Chem 2006; 97: 705-711.

Akinpelu DA, Aiyegoro OA, Okoh AI. The in vitro antioxidant property of methanolic extract of Afzelia Africana (Smith.). J Med Plants Res 2010; 4: 2021- 2027.

Goncalves S, Gomes D, Costa P, Romano A. The phenolic content and antioxidant activity of infusions from Mediterranean medicinal plants. Ind Crop Prod 2013; 43: 465- 471.

Kesraoui O, Marzouki MN, Maugard T, Limam F. In vitro evaluation of antioxidant activities of free and bound phenolic compounds from Posidonia oceanica (l.) Delile leaves. Afr J Biotechnol 2011; 10: 3176-3185.

Bouhdid S, Skali SN, Idaomar M, Zhiri A, Baudoux D, Amensour M et al. Antibacterial and antioxidant activities of Origanum compactum essential oil. Afr J Biotechnol 2008; 7: 1563-1570.

Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Medica 1982; 45: 31-34.


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