The Prognosis Value of CDH-1 Methylation – The Epigenetic Biomarker in Nasopharyngeal Carcinoma: Systematic Review and Meta-Analysis


  • Ho Chi Minh City Open University, Faculty of Biotechnology, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City, 700000, Viet Nam
  • Ho Chi Minh City University of Science, Faculty of Biology and Biotechnology, Hồ Chí Minh, 700000, Viet Nam


Background: The phenome of CDH-1 gene methylation has been reported to be associated with the nasopharyngeal tumorigenesis. Objective: Aiming to evaluate the association between the CDH-1 gene methylation and nasopharyngeal cancer, and its correlation could be used as an epigenetic biomarker for nasopharyngeal cancer risk based on metaanalysis. Materials and Methods: Relevant articles were identified by searching MEDLINE database. The frequency and Odds Ratio (OR) were applied to estimate the effect of CDH-1 methylation based on random-/fix-effects models. Results: Total of 12 studies, including 500 samples from NPC patients and 201 samples from non-cancerous samples, were enrolled in current study. Overall, the frequency of CDH-1 gene methylation were 48.50% and 3.09% in the case and control group, respectively. The association between the CDH-1 gene methylation and risk of NPC was also confirmed by calculating OR value of 15.33 (95% CI = 7.82-30.06), based on the fix-effects model. Additionally, the significant association was also found between the methylation of CDH-1 gene and subgroups. Conclusion: this meta-analysis provides scientific evidences to suggest the CDH-1 methylation was the potential biomarker for risk of NPC.


Nasopharyngeal meta-analysis, CDH-1, epigenetic biomarker.

Subject Discipline

Pharmaceutical and Medical Biotechnology

Full Text:


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