Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis


  • Apollo Institute of Medical Sciences and Research, Department of Biochemistry, Hyderabad, Telangana, 500033, India
  • Kamineni Institute of Medical Sciences, Principal & Professor, Department of Biochemistry, Telangana, India
  • Apollo Institute of Medical Sciences and Research, Department of Pharmacology, Hyderabad, Telangana, 500033, India


To assess adjustments in star oxidant and cancer prevention agent state in pre and post hemodialysis patients experiencing ceaseless renal disease. The study was led on 100 perpetual renal disappointment patients going to outpatient division of nephrology dialysis unit in relationship with bureau of organic chemistry at Kamineni establishment of therapeutic Sciences, Narketpally, Nalgonda district, Telangana. Age between 30-70 years of either sex measuring their estimated oxidant levels of serum malondialdehyde, serum protein carbonyls and anti-oxidant levels of serum superoxide dismutase, serum catalase prior and then afterward the dialysis session coordinated controls. In the present study, we have observed significant increase in levels of pro-oxidants serum malondialdehyde and serum protein carbonyls fixation and there was reduction in chemical action of cell reinforcement serum superoxide dismutase and serum catalase. Our study highlights the need of screening of cancerous agents in renal Patients in regular intervals for better treatment outcomes and also to improve quality of life of the patients.


Antioxidants, Chronic Kidney Disease, Dialysis, Pro Oxidants

Full Text:


Anthony SF, Dennis LK, Eugene B, Stephen LH, Larry J. Chronickidney disease. In: Anthony SF, Dennis LK, Eugene B, Stephen LH, Larry J, editors. Harrison's principles of internal medicine. 17th ed. New Delhi: McGraw-Hill Companies; 2008. p. 1761–71.

Dakshinamurthy KV, Rao PVLNS, Saibaba KSS, Sheela RB. Antioxidant status in patients on maintenance hemodialysis. Indian J Nephrol. 2002; 12:77–80.

Ichikawa I, Kiyama S, Yoshioka T. Renal antioxidant enzymes: Their regulation and function. Kidney Int. 1994; 45:1–9. PMid:8126996. Available from:

Massy ZA, Nguyen-Khoa T. Oxidative stress and chronic renal failure: Markers and management. J Nephrol. 2002; 15: 336–41. PMid:12243361.

Barber A, Bernheim F. Lipid peroxidation: Its measurements, occurrence and significance in animal tissues. Adv Gerontal Res. 1967; 2:355–03. PMid:5339163.

Fridovich I. The biology of oxygen radicals. Science. 1978; 201:875–80. PMid:210504 Available from:

Southorn PA, Powis G. Free radicals in medicine I and II. Mayo Clinic Proc. 1988; 63:381–08. Available from:

Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol. 2001; 54:170–80. PMCid:PMC1731363. Available from:

Martin-Mateo MC, del Canto-Jafiez E, Barrero-Martinez MJ. OS and enzyme activity in ambulatory renal patients undergoing continuous peritoneal dialysis. Renal Fail. 1998; 20:117–24. Available from:

Mimic-Oka J, Simic T, Djukanovic L, Reljic Z, Davicevic Z. Alteration in plasma antioxidant capacity in various degrees of CRF. Clin Nephrol. 1999; 51:233–41. PMid:10230556.

Fawcett JK, Scott. A rapid and precise method for the determination of urea. J Clin Path. 1960; 13:156–9. PMid:13821779 PMCid:PMC480024. Available from:

Patton. CJ, Crouch SR. Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammonia. Anal Chem. 1977; 49:464–9. Available from:

Bird RP, Draper HH. Comparative study on different methods of MDA determination. Methods Enzymol. 1984; 105:299–05. Available from:

Menesve E, Sivrikaya A, Karagozoglu E, Ali Muhtar Tiftik. Study of elements, antioxidants and lipid Peroxidation in hemodialysis patients. Turk J Med Sci. 2006; 36: 279–84.

Aebi HE, Bergmeyer HU. Catalase in methods of enzymatic analysis. 3rd ed. Weinheim: Verlag Chemie. 1983; 273–86.

Esma M, Abdulla S, Emrah K, Ali Muhtar T. Study of elements, antioxidants and lipid Peroxidation in hemodialysis patients. Turk J Med Sci. 2006; 36:279–84.

Himmelfarb J, McMonagle E, McMenamin E. Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int. 2000; 58:2571–8. PMid:11115093. Available from:

Ward RA, Ouseph R, Mcleish KR. Effects of high-fluxhemodialysis on oxidant stress. Kidney International. 2003; 63:353–9. PMid:12472803. Available from:

Sohji N, Kazumasa A, Aki H, Michihiro G, Atsushi U. Favourable effect of hemodialysis on decreased serum antioxidant activity in hemodialysis patients demonstrated by electron spin resonance. Journal of the American Society of Nephrology. 1997; 8:1157–63.

Paik-Seong L, Yau-Huei W, York Leng Y, Benny K. Enhanced oxidative stress in hemodialysis patients receiving intravenous iron therapy. Nephrol Dial Transplant. 1999; 14:2680–7. Available from:

Necip I, Ahmet V. Evaluation of oxidative damage during hemodialysis with different dialysis membranes. T Klin Med Res. 2002; 20:60–4.


  • There are currently no refbacks.