A Cross-Sectional Study to Find the Correlation Between Age and BMI with Bone Mineral Density in Pre and Post-Menopausal Women
DOI:
https://doi.org/10.18311/jeoh/2024/43626Keywords:
Bone Mineral Density, Osteopenia, OsteoporosisAbstract
Osteoporosis is a silent disease and it generally leads to fragility fracture. The present study compares the Bone Mineral Density (BMD) by portable ultrasonic bone densitometer in premenopausal and post-menopausal women and also examines the association of BMD with age and Body Mass Index (BMI). A cross-sectional study was done among 79 apparently healthy females grouped as pre and post-menopausal females. An elaborate questionnaire was used and BMD was calculated based on the Tscore by a portable ultrasonic bone densitometer. Similar osteopenic changes were observed in both pre and post-menopausal females while osteoporosis was more prevalent in post-menopausal females. There was an inverse correlation between BMI and BMD in both pre and post-menopausal females but it was only significant in premenopausal women. Additionally, there was an increased frequency of osteopenic changes in our participants which suggested a higher risk of osteoporosis in women hence there is a need to treat osteopenia early to prevent osteoporosis and risk of fragility fractures.
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Copyright (c) 2024 Ankita Juyal
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-05-30
Published 2024-08-29
References
Manolagas SC. Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000; 21(2):115-37. https://doi.org/10.1210/edrv.21.2.0395 PMid:10782361.
Holroyd C, Cooper C, Dennison E. Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab. 2008; 22:671-85. https://doi.org/10.1016/j.beem.2008.06.001 PMid:19028351.
Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol. 2006; 194:S3-11. https://doi.org/10.1016/j.ajog.2005.08.047 PMid:16448873.
Kleerekoper M, Al-Khayer F. Osteoporosis, overview. Encyclopedia of Endocrine Diseases. 2004; 3:425-31. https://doi.org/10.1016/B0-12-475570-4/00952-5
Cecily HSJ. Early detection and prevention of osteoporosis among pre and Post-menopausal women in Saudi Arabia. Clin Nurs Res. 2020; 29(1):48-55. https://doi.org/10.1177/1054773818769209 PMid:29631417.
Korkmaz N, Tutoğlu A, Korkmaz I, et al. The relationships among vitamin D level, balance, muscle strength and quality of life in postmenopausal patients with osteoporosis. J Phys Ther Sci. 2014; 26:1521-6. https://doi.org/10.1589/ jpts.26.1521 PMid:25364102. PMCid: PMC4210387.
Handa R, Ali Kalla A, Maalouf G. Osteoporosis in developing countries. Best Pract Res Clin Rheumatol. 2008; 22:693-708. https://doi.org/10.1016/j.berh.2008.04.002 PMid:18783745.
WHO: Scientific group on the prevention and management of osteoporosis. Prevention and management of osteoporosis: Report of a WHO Scientific Group. Geneva, PA. Geneva: World Health Organization; 2000. p. 1-3.
Fahim F. The magnitude of low bone mineral [corrected] density in middle and old age women. J Pak Med Assoc 2005; 55:500- 2. Erratum in: J Pak Med Assoc. 2006; 56:146.
Nelson HD, Helfand M, Woolf SH, Allan JD. Screening for postmenopausal osteoporosis: A review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2002; 137:529-41. https://doi.org/10.7326/0003-4819-1376-200209170-00015 PMid:12230356.
Hui SL, Slemenda CW, Johnston CC., Jr. The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int. 1990; 1:30-4. https://doi.org/10.1007/BF01880413 PMid:2133638.
Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993; 341(8837):72-5. https://doi.org/10.1016/01406736(93)92555-8 PMid:8093403.
Eisman JA, Kelly PJ, Morrison NA, Pocock NA, Yeoman R, Birmingham J, Sambrook PN. Peak bone mass and osteoporosis prevention. Osteoporos Int. 1993; 3(1):56-60. https://doi.org/10.1007/BF01621865 PMid:8499027.
World Health Organization. Obesity: Preventing and managing the global epidemic. Geneva, Switzerland: World Health Organization; 2000.
Lloyd JT, Alley DE, Hawkes WG, Hochberg MC, Waldstein SR, Orwig DL. Body mass index is positively associated with bone mineral density in US older adults. Arch Osteoporos. 2014; 9:175. https://doi.org/10.1007/s11657-014-0175-2 PMid:24664472.
Greco EA, Fornari R, Rossi F, Santiemma V, Prossomariti G, Annoscia C, Aversa A, Brama M, Marini M, Donini LM, Spera G, Lenzi A, Lubrano C, Migliaccio S. Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract. 2010; 64(6):817-20. https://doi.org/10.1111/j.17421241.2009.02301.x PMid:20518955.
Gkastaris, K. et al. Obesity, osteoporosis and bone metabolism. J Musculoskelet Neuronal Interact. 2020; 20:72-381.
Addison O, Marcus RL, Lastayo PC, Ryapn AS. Intermuscular fat: A review of the consequences and causes. Int J Endocrinol. 2014; 309570. https://doi.org/10.1155/2014/309570 PMid:24527032 PMCid: PMC3910392.
Almeida, M. et al. Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev. 2017; 97(1):135-87. https://doi.org/10.1152/physrev.00033.2015 PMid:27807202 PMCid: PMC5539371.
Pasco JA et al. Serum leptin levels are associated with bone mass in non-obese women. J Clin Endocrinol Metab. 2001; 86(5):1884-7. https://doi.org/10.1210/jc.86.5.1884
Ruhl CE, Everhart JE. Relationship of serum leptin concentration with bone mineral density in the United States population. J Bone Miner Res. 2002; 17(10):1896-1903. https://doi.org/10.1359/jbmr.2002.17.10.1896 PMid: 12369793.
Fasshauer M et al. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2002; 290(3):1084-9. https://doi.org/10.1006/bbrc.2001.6307 PMid:11798186.