Chronic Exposure to Heavy Metals Declines Sperm Quality and Damages Tissue Architecture

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Authors

  • Sujata De Chaudhuri
     Department of Zoology, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata – 700120, West Bengal ,IN

DOI:

https://doi.org/10.18311/jeoh/2022/30819

Keywords:

Male rats, reproduction, Heavy metal, testis, liver
Reproductive Toxicology

Abstract

This study aimed to assess the toxic effects of heavy metals in adult male rats after chronic exposure in early life stages. Juvenile male Wistar rats were kept in constant supply of drinking water having heavy metal salts such as Sodium Arsenite, Cadmium Chloride and Lead Acetate of dose 100 times higher than Maximum Contamination Limit (MCL; laid done by US EPA, 2009) for 3 months along with control rats with a supply of heavy metal free water. The result showed decreased sperm count and increase in abnormal sperm in all treated cases. Histopathology showed that testes and liver tissues of treated rats were severely damaged. Thus, this study showed that chronic exposure to heavy metals such as Arsenic, Cadmium and Lead in juvenile period may result in reduced reproductive capacity at later stage of life.

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Published

2022-09-30

How to Cite

De Chaudhuri, S. (2022). Chronic Exposure to Heavy Metals Declines Sperm Quality and Damages Tissue Architecture. Journal of Ecophysiology and Occupational Health, 22(3), 117–121. https://doi.org/10.18311/jeoh/2022/30819

Issue

Volume 22, issue 3, September 2022

Section

Articles

License

Copyright (c) 2022 Sujata De Chaudhuri

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2022-07-27
Accepted 2022-09-14
Published 2022-09-30

 

References

Agency for Toxic Substances and Disease Registry. Atlanta (ATSDR). Toxicological profile for arsenic 2007 [displayed 3 January 2012].

Agency for Toxic Substances and Disease Registry (ATSDR). Public Health Statement for Cadmium, September 2008 [displayed 3 January 2012]. Available at http://www.atsdr.cdc.gov/ phs/phs.asp?id=46&tid=15

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for lead 2007 [displayed 3 January 2012] Available at http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf

Siu ER, Mruk DD, Porto CS, Cheng CY. Cadmium-induced Testicular Injury Toxicol Appl Pharmacol. 2009 Feb 21; 238(3):240–9. DOI: https://doi.org/10.1016/j.taap.2009.01.028

Sarkar M, Chaudhuri G, Chattopadhayay A, Biswas NM. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J Androl. 2003 Mar; 5:27–31.

Thompson J, Bannigan J. Cadmium: Toxic effects on the reproductive system and the embryo. Reprod Toxicol. 2008 Apr; 25(3):304–15. PMid: 18367374. https://doi.org/10.1016/j.reprotox. 2008.02.001 DOI: https://doi.org/10.1016/j.reprotox.2008.02.001

Mukhopadhyay D, Mitra A, Nandi P, Varghese AC, Murmu N, Chowdhury R, Chaudhuri K, Bhattacharyya AK. Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Syst Biol Reprod Med. 2009 Nov; 55(5-6):188–92. PMid: 19938953. https://doi. org/10.3109/19396360903114429 DOI: https://doi.org/10.3109/19396360903114429

Lancranjan I, Popescu HI, GAvanescu O, Klepsch I, Serbanescu M. Reproductive ability of workmen occupationally exposed to lead. Env Health. 1975 Aug; 30(8):396–401. PMid: 1155972. https://doi.org/10.1080/00039896.1975.10666733 DOI: https://doi.org/10.1080/00039896.1975.10666733

De Chaudhuri S, Kundu M, Banerjee M, Das JK, Majumdar P, Basu S, Roychoudhury S, Keshav K, Singh KK, Giri AK. Arsenic-induced health effects and genetic damage in keratotic individuals: Involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutat Res. 2008 Nov 26; 659(1-2):118–25. PMid: 18249029. https://doi.org/10.1016/j. mrrev.2007.11.008 DOI: https://doi.org/10.1016/j.mrrev.2007.11.008

Goyal T, Mitra P, Singh P, Sharma S, Sharma P. Assessement of blood lead and cadmium levels in occupationally exposed workers of Jodhpur, Rajasthan. Indian J Clin Biochem. 2021 Jan; 36(1):100–7. PMid: 33505134 PMCid: PMC7817726. https://doi. org/10.1007/s12291-020-00878-6 DOI: https://doi.org/10.1007/s12291-020-00878-6

World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. Cambridge, UK: Cambridge University Press, 1980, 1987, 1992, 1999.

Roy Chowdhury A, Rao RV, Gautam AK. Histochemical changes in the testes of lead induced experimental rats. Folia Histochem Et Cytobiol. 1986 Jan; 24(3):233–8.

Roy Chowdhury A, Chinoy NJ, Gautam AK, Rao RV, Parikh DJ, Shah GM, Highland HN, Patel KG, Chatterjee BB. Effect of lead on human semen. Advances in Contraceptive Delivery System. 1986 Jun; 2(2-3):208–10.