Aqueous Extract of Ficus Vogelii Potentiates Changes in Liver Function and Hematological Parameters of Aspirin Treated Rats
Objective: This study was carried out to investigate the possible effect of Ficus vogelii (FV) on liver function and some hematological parameters of male Wistar rats administered with aspirin. Materials and Methods: The animals were divided into 4 groups comprising 5 animals each. Group 1: Normal control group, Group 2: Positive control group which received 500 mg/kg of aspirin for three days. Group 3: Pre-treated with aqueous extract of Ficus vogelii (600 mg/kg body weightbwt) for 14 days and then administered with Aspirin (500 mg/kg bwt) for 3 days. Group 4: received 500mg/kg of aspirin for three days, and then treated with aqueous extract of FV (600 mg/kg bwt) for 14 days. Results: There was a significant decrease (p<0.05) in PCV in the treatment groups 2, 3 and 4 (39.00±5.19, 41.50±2.59 and 41.50±1.91% respectively) when compared to the control group (62.50±1.44%). A significant decrease was recorded in WBC and platelet count in group 3 (pre-treatment) and 4 (treatment groups) (9.6±0.40×10/L and 8.8±1.10 × 10/L respectively) when compared to group 2. A significant decrease was also observed in AST, ALT and ALP levels in FV treated group 4 (9.50±0.29 and 138.50±3.75 μ/L respectively) when compared to group 2 (aspirin-treated group: 27.50±0.87 and 194.50±12.41 μ/L respectively). Conclusion: This extract may thus be useful in ameliorating Aspirin induced liver damage.
Fernando B. Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World Journal of Gastroenterology. 2010; 16:5651–61. https://doi.org/10.3748/ wjg.v16.i45.5651.PMid:21128314 PMCid:PMC2997980
Hanson PD, Maddison JE. Non-steroidal antiinflammatory drugs and chondroprotective agents: Small animal clinical pharmacology, Saunders London: Second edition; 2008.p. 287–308. https://doi.org/10.1016/B978-070202858-8 .50015-4
Hunter LJ, Wood DM, Dargan PI. The patterns of toxicity and management of acute non-steroidal antiinflammatory overdose. Open Access Emergency Medicine. 2011; 3:39– 48. https://doi.org/10.2147/OAEM.S22795. PMid:27147851 PMCid:PMC4753966
Klaassen CD. Casarett and Doull’s Toxicology: the basic science of poison, 6th Edition The McGrau-Hill Companies Inc. New York; 2001.
Muraoka S, Miura T. Metabolism of non-steroidal anti-inflammatory drugs by peroxidase: Implication for gastrointestinal mucosal lesions. Yakugaku Zasshi. 2007; 127:749–56. https:// doi.org/10.1248/yakushi.127.749. PMid:17409707
Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature. 2004; 427:630–3.https://doi.org/10.1038/nature02317. PMid:14745453
Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)induced toxicity: Molecular and biochemicalmechanisms, analogues and protective approaches. Critical Reviews in Toxicology. 2001; 31:55–138. https://doi .org/10.1080/20014091111677. PMid:11215692
Ukwueze CS, Ukwueze CO, Nweze EC. Comparative study on the toxic effects of some Non-Steroidal AntiInflammatory Drugs (NSAIDs) in rats. Journal of Animal and Veterinary Advances. 2014; 4:767–71. https://doi .org/10.5455/jva.20141208030829
Jaeschke H, Williams CD, McGill MR, Xie Y,Ramachandran A. Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Food and Chemical Toxicology. 2013; 55:279–89.https://doi.org/10.1016/j.fct.2012.12.063. PMid:23353004 PMCid:PMC3608827
Andrade RJ, Lucena MI, Fernández MC, Pelaez G, Pachkoria K, García-Ruiz E, et. al. Drug-induced liver injury: An analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005; 129:512–21. https:// doi.org/10.1016/j.gastro.2005.05.006. PMid:16083708
Bjornsson E. Review article: Drug-induced liver injury in clinical practice. Alimentary Pharmacology & Therapeutics. 2010; 32:3–13. https://doi.org/10.1111/j.1365-2036.2010.04320.x
Teoh NC, Farrell GC. Hepatotoxicity associated with nonsteroidal anti-inflammatory drugs. Clinical Liver Disease. 2003; 7:401–13. https://doi.org/10.1016/S10893261(03)00022-9
Zimmerman HJ. Editorial: Aspirin-induced hepatic injury.Annals of Internal Medicine. 1974; 80:103–5. https://doi .org/10.7326/0003-4819-80-1-103. PMid:4810329
Russell AS, Sturge RA, Smith MA. Serum transaminases during salicylate therapy. British Medical Journal.1971; 2:428–9. https://doi.org/10.1136/bmj.2.5759.428.PMid:5576002 PMCid:PMC1796143
Traversa G, Bianchi C, Da Cas R, Abraha I, Menniti-Ippolito F, Venegoni M. Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs. British Medical Journal. 2003; 327:18–22.https://doi.org/10.1136/bmj.327.7405.18. PMid:12842950 PMCid:PMC164233
Jain NC. Schalms veterinary hematology. 4th Lea and Febinger. Philadelphia; 1986.
Reagan WJ, Sanders TG, DeNicola DB. Veterinary Hematology: Atlas of Common Domestic Species. Iowa State University Press. Ames; 1998.
Oyedeji KO, Bolarinwa AF, Ojeniran SS. Effect of Paracetamol (acetaminophen) on haematological and reproductive parameters in male albino rats. Journal of Pharmaceutical and Biological Sciences. 2013; 4:65–70.https://doi.org/10.9790/3008-0466570
Bamikole MA, Ikhatua UJ, Arigbede OM, Babayemi OJ, Etela I. An evaluation of the acceptability as forage of some nutritive and anti-nutritive components of the dry matter degradation profile of five species of Ficus. Tropical Animal Health and Production. 2004; 36:157–7.https://doi.org/ 10.1023/B:TROP.0000012104.47814.78. PMid:14998314
Igile GO, Utin IC, Iwara IA, Mgbeje BIA, Ebong PE.Ethanolic extract of Ficus vogelii Ameliorates Dyslipdemia in Diabetic Albino wistar Rats. International Journal of Current Ros Bioscience and plant Biology. 2015; 2:87–96.
Ahmad IT, Qureshi TA, Sadique U, Khan SA, Ahmed S.Hematologic effect of diclofenac sodium in goats. Journal of Animal and Plant Sciences. 2013; 1:103–7.
Abatan MO, Lateef I, Taiwo VO. Toxic effects of non-steroidal anti-inflammatory agents in rats. African Journal of Biomedical Research. 2006; 9:219–23. https://doi .org/10.4314/ajbr.v9i3.48909
Egbuna PAC, Joshua PE, Chigbo MU. Antihepatotoxic effects of ficus vogelii ethanol leaf extract on the liver function indices of ccl4 -induced hepatotoxicity in rats. Journal of American Science. 2011; 7:158–63.
Sigma diagnostic. Quantitative, colorimetric determination in serum, plasma or cerebrospinal fluid. 1985; (Procedure No. 505).
Ahmad I, Qureshi TA, Khan FA, Mughal SAK, Sadique U, Shah Z, et al. Evaluation of biochemical effects of dioclofenac sodium in goats. Journal of Animal and Plant Sciences., 2012; 22(2):1–4.
El-Maddawy ZKH, El-Ashmawy IM. Hepato-renal and haematological effects of diclofenac sodium in Rats. Global Journal of Pharmacology, 2013; 7(2):123–32.
Orinya A, Adeshina YA, Raphael JO. Haematological and biochemical studies on the effect of diclofenac sodium on Wistar Rattus norvegicus. International Journal of Biological and Chemical Sciences. 2016; 10(5):2231–42.https://doi.org/10.4314/ijbcs.v10i5.23
Enendu AC, Unekwe PC, Esimone CO, Obi E, Chilaka KC.Protective effect of phenylalanine and glycine on chloramphenicolinduced bone marrow toxicity in albino ratsinfected with Klebsiella Pneumoniae. International Journal of Biological and Chemical Sciences. 2016; 10(1):369–83. https://doi.org/10.4314/ijbcs.v10i1.28
- There are currently no refbacks.