An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats


Affiliations

  • Mumbai Veterinary College, Department of Veterinary Pathology, Mumbai, 400012, Maharashtra, India
  • Maharashtra Animal and Fishery Sciences University, MAFSU, Department of Veterinary Pathology, Nagpur, Maharashtra, 440006, India
  • Mumbai Veterinary College, Department of Veterinary Pathology, Mumbai, Maharashtra, 400012, India
  • Mumbai Veterinary College, Department of Veterinary Public Health, Mumbai, Maharashtra, 400012, India
  • Mumbai Veterinary College, Department of Veterinary Pharmacology and Toxicology, Mumbai, Maharashtra, 400012, India
  • Mumbai Veterinary College, Mumbai, Maharashtra, 400012, India

Abstract

The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.

Keywords

Acute Toxicity, OECD Guideline 423, Tylophora indica, Wistar Rats

Subject Discipline

Toxicology

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