Preliminary Toxicological Report of Metformin Hydrochloride Loaded Polymeric Nanoparticles

Jump To References Section

Authors

  • Unnikrishnan Meenakshi Dhana Lekshmi
     ,IN
  • Pully Neelakanta Reddy
     ,IN

Keywords:

Haemolysis, metformin hydrochloride, polymeric nanoparticles, toxicity

Abstract

Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue. Therefore, there is a pressing need for careful consideration of benefits and side effects of the use of nanoparticles in medicine. This research work aims at providing a balanced update of this exciting potentially toxicological effect of manufactured Metformin hydrochloride loaded polymeric nanoparticles. To assess the toxicities systematically on the functions of various tissues and organs in rats, the rats were fed with the manufactured polymeric nanoparticles for a period of 30 days repeated oral administration. Variation in the protein, carbohydrate and fat metabolic profile of the rat exposed to nanoparticles were studied by hematobiochemical and pathology profiles. The haemolytic potential of these nanoparticles were determined by means of an in vitro haemolysis assay. All formulations showed haemolytic effect less than 5%. The study revealed that Metformin loaded PMMA and PLGA polymeric nanoparticle did not produce any toxicity.

Downloads

Download data is not yet available.

Downloads

Published

2018-08-14

How to Cite

Lekshmi, U. M. D., & Reddy, P. N. (2018). Preliminary Toxicological Report of Metformin Hydrochloride Loaded Polymeric Nanoparticles. Toxicology International, 19(3), 267–272. Retrieved from http://www.informaticsjournals.com/index.php/toxi/article/view/21759

Issue

Volume 19, Issue 3, September - December 2012

Section

Original Research
Received 2018-08-14
Accepted 2018-08-14
Published 2018-08-14

 

References

Kagan VE, Bayir H, Shvedova AA. Nanomedicine and nanotoxicology: Two sides of the same coin. Nanomedicine 2005;1:313-6.

Colvin V. Potential risks of nanomaterials. Environ Health Saf Soc Publ 2007;4:1-12.

Sarabjeet SS, Hicham F, Baljit S. Open A Review. Nanotechnology based drug delivery systems. J Occup Med Toxicol 2007;2:16.

Jani PU, McCarthy DE, Florence AT. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration. Int J Pharm 1994;105:157-68.

Bockmann J, Lahl H, Eckert Th, Unterhalt B. Titan Blutspiegelvor und nach Belastungsversuchenmit Titandioxid. Pharmazie 2000;55:140-3.

Wang M, Yao J, Chen YJ, Bai XW, Mei SY, Pan WN, et al. A sub chronic Intravenous toxicity study of magnesium fructose 16 diphosphate in beagle dogs. Basic Clin Pharmacol Toxicol 2008;104:93-100.

Zhen C, Huan M, Gengmei X, Chunying C, Yuliang Z, Guang J, et al. Acute toxicological effects of copper nanoparticles in vivo.Toxicol Lett 2006;163:109-20.

Dmitri K, Samy IM, James RS. Metformin: An Update, American Society of Internal Medicine. Ann Intern Med 2002;137:25-33.

Dhanalekshmi UM, Poovi G, Narra K, Neelakanta PR. In vitro characterization and in vivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles. Int J Pharm 2010;396:194-203.

Mehta RT, Hopfer RL, Juliano RL, Lopoz-Berestein G. A comparison of in vitro toxicity and antifungal efficacy of membrane active drugs after liposome encapsulation. Sel Cancer Ther 1989;5:113-7.

Bulmus V, Woodward M, Lin L, Murthy N, Stayton P, Hoffmann A.A new pH responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J Control Release 2003;93: 105-20.

Gelperina SE, Khalansky A, Smirnova ZS, Bobruskin AI, Severin SE. Toxicological studies of doxorubicin bound to polysorbate 80-coated poly (butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. Toxicol lett 2002;126:131-41.

Rodriguez SI, Campillo P, Alexander A, Teresa M, Lercker G, Garcia H. Bio chemical and histopathological effects of dietary oxidized cholesterol in rats. J Appl Toxicol 2009;29:715-23.

Han HM, Clen J, Wing J, Wang TX. Blood compatibility of poly aminodiaminedendrimers and erythrocyte protections. J Biomed Nanotechnol 2010;6:82-92.

Seaton A, Donaldson K. Nanoscience, nanotoxicology, and the need to think small. Lancet 2005;365:923-4.

Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, et al . U n u s u a l i n f l a m m a t o r y a n d fibrogenicpulmonaryresponses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005;289:L698-708.

Peters K, Unger RE, Kirkpatrick CJ, Gatti AM, Monari E. Effects of nano-scaled particles on endothelial cell function in vitro: Studies onviability, proliferation and inflammation. J Mater Sci Mater Med 2004;15:321-5.

Malik N, Patapee WR, Klopsch R, Lorenz K, Frey H, Weener JW, et al.Dendrimers: Relation between structure and biocompatablity.J Control Release 2000;65:133-48.

Kim SY, Sikkim J, Cho SH, SikRha D, Yu I. Twenty eight days oral toxicity, Genotoxicity and gender related tissue distribution of silver nanoparticles in Sprague dawley rats. Inhal Toxicol 2008;20:575-83.

Choksakulnimitr S, Masuda S, Tokuda H, Takakura Y, Hashida M.In vitro cytotoxicity of macromolecules in different cell culture systems. J Control Release 1995;34:233-41.

Rolland A, Begue JM, Le Verge R, Guillouzo A. Increase of doxorubicin penetration in cultured rat hepatocytes by its binding to polymethacrylic nanoparticles. Int J Pharm 1989;53:67-73.

Bala I, Hariharan S, Kumar MN. PLGA nanoparticles in drug delivery the state of art. Crit Rev Ther Drug Carrier Syst 2004;21:387-482.

Ren H, Huang X. Polyacrylate nanoparticles: Toxicity or new nanomedicine? Eur Respir J 2010;36:218-21.