Hematobiochemical Evaluation of Dermal Subacute Cypermethrin Toxicity in Buffalo Calves


  • Guru Angad Dev Veterinary and Animal Sciences University Library, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Ludhiana, Punjab, India
  • Guru Angad Dev Veterinary and Animal Sciences University, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Ludhiana, Punjab, India


Dermal exposure of cypermethrin, a type II synthetic pyrethroid insecticide, at dose rate of 0.25% for 14 consecutive days produced mild signs of toxicity in buffalo calves. It produced significant elevation in the levels of alanine aminotransferase (ALT; 39.5%), aspartate aminotransferase (AST; 32.0%), blood urea nitrogen (BUN; 57.7%), and plasma creatinine (30.0%). Cypermethrin also produced significant decrease in the hemoglobin (Hb) concentration (5.4%), packed cell volume (PCV; 3.4%), and total erythrocytic count (4.0%). Additionally, there was a significant increase in erythrocytic sedimentation rate (ESR; 3.1%). On the basis of the present study, it can be concluded that cypermethrin induces significant biochemical and hematological alterations in buffalo calves when exposed dermally.


Biochemical, buffalo calves, cypermethrin, dermal, hematology, toxicity

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