Haematolohical Profile of Subacute Oral Toxicity of Molybdenum and Ameliorative Efficacy of Copper Salt in Goats

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Authors

  • Kusum .
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • R. Rania
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • P. K. Verma
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • N. K. Pankaj
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • V. Kant
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • J. Kumar
     Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN
  • A. K. Srivastava
     Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir ,IN

Keywords:

Ammonium molybdate, copper sulfate, goats, hematological profile
Herpetology

Abstract

Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into alterations in normal hematological profile. In the present study, ammonium molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) was administered orally for 30 consecutive days in healthy goats of group 1 and 2, respectively, to access the effect on the hematological profile on different predetermined days of dosing. Administration of ammonium molybdate alone produced significant decline in the mean values of hemoglobin (Hb), packed cell volume (PCV), total leukocyte count (TLC), total erythrocyte count (TEC), and mean corpuscular hemoglobin concentration (MCHC), with a significant increase in neutrophil level and mean corpuscular volume (MCV). However, values of erythrocyte sedimentation rate, mean corpuscular hemoglobin, and differential leukocyte count were not significantly altered. On comparing observations of ameliorative group with the group 1 goats, it is concluded that the ameliorative copper salt has beneficial effects in alleviating the alterations in the values of Hb, PCV, TLC, TEC, MCV, MCHC, and neutrophils.

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Published

2018-05-16

How to Cite

., K., Rania, R., Verma, P. K., Pankaj, N. K., Kant, V., Kumar, J., & Srivastava, A. K. (2018). Haematolohical Profile of Subacute Oral Toxicity of Molybdenum and Ameliorative Efficacy of Copper Salt in Goats. Toxicology International, 17(2), 82–85. Retrieved from http://www.informaticsjournals.com/index.php/toxi/article/view/21183

Issue

Volume 17, Issue 2, July-December 2010

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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