Protective Role of Tinospora cordifolia against Lead-induced Hepatotoxicity

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Authors

  • V. Sharma
     Bioscience and Biotechnology Department, Banasthali University, Banasthali - 304 022, Tonk, Rajasthan ,IN
  • D. Pandey
     Bioscience and Biotechnology Department, Banasthali University, Banasthali - 304 022, Tonk, Rajasthan ,IN

Keywords:

Biochemical changes, histopathology, lead nitrate, liver, mice, Tinospora cordifolia
Phylogenetics

Abstract

The importance of Tinospora cordifolia stem and leaves extract was investigated for its possible hepatoprotective effect in Swiss albino male mice against lead nitrate induced toxicity. Oral administration of plant extracts prevented the occurrence of lead nitrate induced liver damage. The decreased level of tissue enzymes, i.e., superoxide dismutase (SOD), catalase (CAT) and increased level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and acid phosphatase (ACP) were observed in mice treated with lead. Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice. These biochemical observations were supplemented by histopathology/histological examinations of liver section. Results of this study revealed that plant extract could afford protection against lead-induced hepatic damage.

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Published

2018-05-15

How to Cite

Sharma, V., & Pandey, D. (2018). Protective Role of <i>Tinospora cordifolia</i> against Lead-induced Hepatotoxicity. Toxicology International, 17(1), 12–17. Retrieved from http://www.informaticsjournals.com/index.php/toxi/article/view/21157

Issue

Volume 17, Issue 1, January-June 2010

Section

Original Research
Received 2018-05-14
Accepted 2018-05-14
Published 2018-05-15

 

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