Metamitron-induced changes in biochemical profile and cytotoxicity in black Bengal goats

Jump To References Section

Authors

  • Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226015 ,IN
  • Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252 ,IN
  • Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252 ,IN
  • Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252 ,IN
  • Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252 ,IN
  • Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences Mohanpur, Nadia-741252 ,IN
  • Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226015 ,IN

Keywords:

Glutathione, goat, lipid peroxidation, metamitron, toxicity, triazine herbicide

Abstract

A non-toxic dose of metamitron (triazine herbicide) was determined in black Bengal goats by trial and error. Hematological parameters like total count, Hb percentage, ESR, biochemical parameters like blood sugar, pyruvic acid, LDH, AChE and tissue biochemical parameters like ALT, AST activity, reduced glutathione level and lipid peroxidation level were estimated in black Bengal goats after oral administration of a single dose of metamitron @30 mg/kg body weight (b.wt.). Histopathological studies were also carried out in tissue sections of liver, kidney, spleen, thyroid, heart and brain. No significant changes were found in experimental subjects when compared to control indicating that metamitron @30 mg/kg b.wt. may be a non-toxic dose to goats and can be used safely in agricultural field.

Downloads

Download data is not yet available.

Published

2018-04-05

How to Cite

D., C., S. K., D., A., K., A. K., C., T. K., M., D. K., B., & Luqman, S. (2018). Metamitron-induced changes in biochemical profile and cytotoxicity in black Bengal goats. Toxicology International, 16(1), 21–26. Retrieved from http://www.informaticsjournals.com/index.php/toxi/article/view/20839

Issue

Section

Original Research
Received 2018-04-05
Accepted 2018-04-05
Published 2018-04-05

 

References

Augustinson, KB (1957): Assay of cholinesterase in Methods of Biochemical Analysis, Inter Science Publishers Inc. USA

Bergmayer, HU, Bernet, E and Hess, B (1974): Lactate dehydrogenase, In: Methods of Enzymatic Analysis, Academic Press, London, p 736.

Coffin, DL (1953): Manual of Veterinary Clinical Pathology, 3rd edition, Comstock, Ithaca, New York., USA.

Debnath, SC, Kundu, A, Das, SK, Mandal, TK, Bhattacharyya, A, Choudhury, A and Chakraborty, AK (2003): Toxicokinetics, recovery, and metabolism of metamitron in Goat. J. Agric. Food Chem., 51: 5977-5984.

Griffith, DW (1980): Determination of glutathione and glutathione disulphide using glutathione reductase and 2 vinyl pyridine. Anal. Biochem., 106: 207.

Johnson, AE, Kampen, KR and Van, WB (1972): Effects on cattle and sheep of eating hay treated with the triazine herbicides, atrazine and prometone. Am. J. Vet. Res., 33: 1433-1438.

Juliet, S, Mandal, TK, Mal, B, Chowdhury, A, Bhattacharyya, A and Chakraborty, AK (1998): Metabolic study of isoproturon in goats following a single oral administration :toxicokinetics and recovery . J. Agric. Food Chem., 46: 178-183.

Klaassen, CD (2003): Casarett & Doull's, Toxicology: The Basic Science of Poisons. 6th edition, McGraw Hill Medical Publishing Division. p.790-796.

Lardy, HA (1964): Manometric Techniques, In: W.W.Umbreit, R.H.Bunis, J.F.Stanfer, 4thedition, Burgess Publishing Company, USA.

Lillie, RD and Fullmer, HM (1976): Histopathological Technique and Practical Histochemistry. 4th edition, McGraw Hill Book Company, New York, USA.

Nair, V and Turner, GA (1984): The thiobarbituric acid test for lipid peroxidation: Structure of the adduct with malonaldehyde. Lipids, 19: 804.

Somogyi, N (1945): Practical Clinical Biochemistry, In: 4th edition of Harrold Valey, The English Language Book Society (ELBS), Great Britain.

Schalm, OW, Jain, NC and Carrol, EJ (1975): Veterinary Hematology, In: 3rd edition of Lead and Febiger, Philadelphia, USA.

Snedecor, GW and Cochran, WG (1994): Statistical Methods, 8th edition, Affiliated East-West Press, New Delhi, India, p.53-55

Tomlin, CDS (1997): The pesticide manual 11th edition, British Crop Protection Council, Faruham, Surrey, UK.

Wootton, IDP (1974): Manometric Technique, In: 4th edition of W.E.Umbert, R.H.Burris, J.F.Stanfer, Burgess Publishing Company, USA.

Yatazidis, Y (1960): Measurement of transminase in serum. Nature, 18: 79-80.