A Study of Hematological Profile in Patients of Chronic Renal Failure Undergoing Hemodialysis at a Tertiary Health Care Institute

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Authors

  • PG resident,Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra,India ,IN
  • Associate Professor, Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital and Research Centre, Nashik -422003, Maharashtra,India ,IN
  • Professor and Head, Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra ,IN
  • PG resident,Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra,India ,IN

Keywords:

Anemia, Bleeding Time, Clotting Time, Complete Blood Count, Hemodialysis, Normocytic Normochromic

Abstract

The complete blood count, peripheral blood smear, bleeding time, clotting time and renal function tests of 114 patients of chronic renal failure who had required hemodialysis for a period of at least 3 months prior to the commencement of this study were studied. The purpose of this study was to investigate the derangements in the haematological profile of chronic renal patients undergoing hemodialysis and to correlate the same with the duration and severity of the renal failure. The principal finding in the study was a 100% prevalence of anemia among chronic renal failure patients, which was predominantly of the normocytic normochromic type. Red blood cell count was reduced in nearly all (93%) of study patients. There was also a strong negative correlation (r = -0.74) between haemoglobin and duration of hemodialysis. However, a significant proportion of cases showed abnormal cells in the peripheral blood cells such as burr cells, schistocytes and pencil cells, suggesting other contributing factors to the anemia. Female patients also showed a significantly greater prevalence of increased red cell distribution width (>15%) as compared to males (p = 0.001) and a lower prevalence of normocytic normochromic anemia as compared to males (p = 0.009). White blood cell counts, platelet counts, and bleeding and clotting times were largely within normal limits, and none of these variables showed a statistically significant association with the duration of hemodialysis, or serum creatinine, or serum blood urea nitrogen. The inference from the study is that anemia is a major comorbidity in end-stage renal failure patients, with many factors contributing to it, and detailed workup and effective treatment of anemia is necessary in this group of patients.

Author Biographies

Arjun Chakravarti, PG resident,Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra,India

Junior Resident, Department of Pathology

Archana Ukey, Associate Professor, Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital and Research Centre, Nashik -422003, Maharashtra,India

Associate Professor, Department of Pathology

Preeti Bajaj, Professor and Head, Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra

Professor and HOD

Department of Pathology

Pradnya Saragade, PG resident,Department of Pathology, Dr.Vasantrao Pawar Medical College Hospital & Research Centre, Nashik -422003, Maharashtra,India

Junior Resident

Department of Pathology

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Published

2017-12-14

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Section

Original Research Article

 

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https://doi.org/10.1016/0002-9343(94)90138-4