To Study the Clinical Profile of Neonatal Sepsis and the Sensitivity of Various Markers of Sepsis Screen

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  • ,IN
  • ,IN
  • ,IN
  • ,IN

Keywords:

Neonatal Sepsis, Clinical Profile, C–reactive Protein
Education and Research

Abstract

Objective: To study the clinical profile of Neonatal Sepsis & the sensitivity of various markers of sepsis screen. Material & Methods: This was a prospective study of neonates admitted to our NICU from January 2010 to October 2011 with diagnosis of neonatal sepsis or those who developed sepsis later on during their stay in NICU. All newborns diagnosed as a case of neonatal sepsis, based on clinical features with positive sepsis screen and/or positive blood culture, were included in our study. Blood Culture & Sensitivity was done with conventional non–automated method using Herley's Broth. Result: Common clinical manifestations of Neonatal Sepsis among the study group were Lethargy (96.36%), Tachypnea (92.73%), Refusal to suck/feeding difficulty (76.36%), Delayed CRT, Poor Pulses (74.55%), Sclerema (61.82%), Gastric Bleeding (45.45%) & Feed Intolerance (45.45%). 46 babies had positive sepsis screen (sensitivity 84%), while 27 babies had a positive blood culture (sensitivity 49.09%).

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2014-01-05

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Original Research Article

 

References

Bang AT, Band RA, Bactule SB, Reddy HM, Deshmukh MD. Effect of home based neonatal care and management of sepsis on neonatal mortality: field trial in rural India. Lancet. 1999 Dec; 354(9194):1955-61.

Wynn JL, Levy O. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol. 2010 Jun; 37(2):307-37.

National Neonatal Perinatal Database. Sepsis, NNF teaching aids: newborn care. Neonatal sepsis. New Delhi: NNPD nodal center, Department of Pediatrics, All India Institute of Medical Sciences; 2004 Apr 12. Report 2002-03.

Shankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr. 2008 Mar; 75(3):261-66.

Stoll BJ. Infections of the neonatal infant. In: Kliegman RM, Jenson HB, Behrman RE, Stanton BF, editors. Nelson textbook of pediatrics. 18th edn. New Delhi: Saunders; 2008. p. 794-811.

Deorari AK. Changing pattern of bacteriologic profile in neonatal sepsis among intramural babies. J Neonatol. 2006; 20(1):8-15.

Aggarwal R, Sankar MJ, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr. 2001; 68(12):1143-47.

Jajoo M, Kumar V, Jain M, Kumari S, Manchanda V. Intravenous colistin administration in neonates. J Pediatr Infect Dis. 2011; 30(3):218-21.

Misquith R, Saldanha P, Shenoy VK, Rai SB. The use of buffy coat smear for diagnosis of neonatal septicemia. Karnataka Pediatric Journal. 2004; 18(1):9-13.

Singh M. Care of the newborn. 7th ed. New Delhi: Sagar publications; 2010.

Tallur SS, Kasturi AV, Nadgir SD, Krishna BS. Clinico-bacteriological study of neonatal septicemia in Hubli. Indian J Pediatr. 2000; 67(3):169-74.

Kuruvilla KA, Pillai S, Jesudason M, Jana AK. Bacterial profile of sepsis in a neonatal unit in South India. Indian Pediatr. 1998; 35:851-58.

Ahmed AS, Chowdhury MA, Hoque M, Darmstadt GL. Clinical and bacteriological profile of neonatal septicemia in a tertiary level pediatric hospital in Bangladesh. Indian Pediatr. 2002; 39(11):1034-39.

Khatua SP, Das AK, Chatterjee BD, Ghose B, Saha A. Neonatal septicemia. Indian J Pediatr. 1986; 53(4):509-14.

St Geme JW Jr, Murray DL, Carter J, Hobel CJ, Leake RD, Anthony BF, Thibeault DC, Ross IB, Drage JS. Perinatal bacterial infection after prolong rupture of amniotic membranes: An analysis of risk and management. J Pediatr. 1984; 104(4):509-14.

Roy I, Jain A, Kumar M, Agarwal SK. Bacteriology of neonatal septicemia in tertiary care hospital of northern India. Indian J Med Micro. 2002; 20(3):156-59.

Gerdes JS. Diagnosis and management of bacterial infection in neonate. Pediatric Clin N Am. 2004; 51:939-59.

Ghosh S, Mittal M, Jaganathan G. Early diagnosis of neonatal sepsis using a hematological scoring system. Ind J Med Sci. 2001; 55(9):495-500.