A Study of Association of Diabetes Mellitus and Vitiligo Patients
The most accepted pathogenesis of vitiligo is autoimmune theory and as a result vitiligo is known to be associated with many autoimmune diseases one of which is diabetes mellitus. A comparative cross-sectional study was done in Department of Dermatology in a tertiary care institute. Eighty patients of vitiligo and eighty controls in the age group of 12-60 years were investigated for fasting blood glucose levels. Five (6.25%) out of eighty patients with vitiligo were found to have diabetes mellitus. This study indicates that all the patients of vitiligo must be screened for diabetes mellitus, for its early diagnosis, to avoid its adverse impact on health status.
Mohamed Allam, Hassan Riad. Concise review of recent studies in vitiligo. Qatar Med. J. 2013; 2013(2):1–19. https:// doi.org/10.5339/qmj.2013.10. PMid: 25003059, PMCid: PMC4080492.
Ying Jin, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, Spritz RA. NALP1 in VitiligoAssociated Multiple Autoimmune Disease. N. Engl. J. Med. 2007; 1216–25. https://doi.org/10.1056/NEJMoa061592. PMid:17377159.
Amerio P, Tracanna M, De Remigis P, Betterle C, Vianale L, Marra ME, Di Rollo D, Capizzi R, Feliciani C, Tulli A. Vitiligo associated with other autoimmune diseases: Polyglandular autoimmune syndrome types 3B+C and 4, Clin. Exp. Dermatol. 2006; 31(5):746–9. https://doi.org/10.1111/j.1365-2230.2006.02171.x. PMid:16803462.
Choi, Davida; Isedeh, Presciliab, Hamzavi IH. Vitiligo: A review of the pathogenesis. J. Egypt, Women’s Dermatologic Soc. 2014; 11(3):145–58.
Kumar K, Sai Priya, Ruchita Sharma, Umesh Kapoor, Mandeep Saini YB. Autoimmune Thyroid Disease in Patients with Vitiligo: Prevalence Study in India, AACE J. 2012; 18(2):194–9. https://doi.org/10.4158/EP11205.OR.
Sacchidanand S, Chetan Oberai, ACI. IADVL Textbook of Dermatology 4th Edition. Fourth. S. Sacchidanand, Chetan Oberai and ACI, editor. Bhalani Publishing House; 2015. p. 1312−13.
Alvin C. Powers. Diabetes mellitus Harrison’s Principle of Internal Medicine.18th ed. 18th ed. D. L, editor. McGrawHill; 2012. p. 2968−3003.
Nunes DH, Maria L, Esser H. Investigation, An Bras Dermatol. 2011; 86(2):241–8. https://doi.org/10.1590/ S0365-05962011000200006. PMid: 21603806.
Moradi S, Ghafarpoor G. Thyroid dysfunction and thyroid antibodies in Iranian patients with vitiligo, Indian J.
Dermatol. 2008 Jan; 53(1):9. https://doi.org/10.4103/00195154.39733. PMid: 19967010, PMCid: PMC2784592.
Biswas M, Chattopadhyay A, Mridha K, Biswas T, Biswas J, Hassan SK. A study on association between Vitiligo and Thyroid Dysfunction, IOSR J. Dent. Med. Sci. Ver. IX. 2015; 14(10):2279–861.
Patil S, Gautam M, Nadkarni N, Saboo N, Godse K, Setia MS. Gender differences in clinic epidemiological features of vitiligo: A cross-sectional analysis, ISRN Dermatol. 2014; 2014:186197. https://doi.org/10.1155/2014/186197. PMid: 24696786, PMCid: PMC3947737.
Saleem K, Azim W. Association of Vitiligo with other Autoimmune Disorders, Diabetes Case Reports. 2016; 1–3.
Narita T, Oiso N, Fukai K, Kabashima K, Kawada A, Suzuki T. Generalized Vitiligo and Associated Autoimmune Diseases in Japanese Patients and Their Families. Allergol Int.; 60.
Handa S, Kaur I. Vitiligo: Clinical findings in 1436 patients, J. Dermatol. 1999 Oct; 26(10):653–7. https://doi.org/10.1111/j.1346-8138.1999.tb02067.x. PMid: 10554431.
Kasumagic-Halilovic E, Prohic A, Begovic B, OvcinaKurtovic N. Association between Vitiligo and Thyroid Autoimmunity, J. Thyroid Res. 2011; 2011:1–3. https://doi.org/10.4061/2011/938257. PMid: 21747969, PMCid: PMC3121018.
Olasode OA, MBBCH FWACP. Why vitiligo in diabetes, Egyptian Dermatology Online Journal, 1(2):8. Egyptian Dermatology Online Journal, 2005; 1(2):8.
Dawber RP. Clinical associations of vitiligo, Postgrad. Med. J. 1970 May; 46(535):276–7. https://doi.org/10.1136/ pgmj.46.535.276. PMid: 5448375, PMCid: PMC2467025.
Gopal KVT, Raghurama Rao G, Harikishan Kumar Y. Increased prevalence of thyroid dysfunction and diabetes mellitus in Indian vitiligo patients: A case-control study, Indian Dermatol. Online J. 2014; 5(4):456–60. https://doi.org/10.4103/2229-5178.142493. PMid: 25396128, PMCid: PMC4228640.
Raveendra L, Hemavathi RN, Rajgopal S. A Study of Vitiligo in Type 2 Diabetic Patients, Indian J. Dermatol. 2017; 62(2):168–70. https://doi.org/10.4103/ijd.IJD_360_16. PMid: 28400636, PMCid: PMC5363140.
Laberge G, Mailloux CM, Gowan K, Holland P, Bennett DC, Fain PR, et al. Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo.Pigment Cell Res. 2005 Jul 19;18(4):300–5. https://doi.org/10.1111/j.1600-0749.2005.00242.x. PMid: 16029422.
Boisseau-Garsaud AM, Garsaud P, Calès-Quist D, Hélénon R, Quénéhervé C, Claire RC. Epidemiology of vitiligo in the French West Indies (Isle of Martinique), Int. J. Dermatol. 2000 Jan; 39(1):18–20. https://doi.org/10.1046/j.13654362.2000.00880.x. PMid: 10651958.
Ahmad Nofal EA, Nofal A, Khater MH, Gharib K, Khalifa N. Vitiligo and associated autoimmune diseases in Zagazig University Hospitlas, Sharkia Governate, Egypt. J. Pigment Disord. 2015 Nov 5; 2(1). https://doi.org/10.4172/23760427.1000154.
Gopal KVT, Rama Rao GR, Kumar YHK, Appa Rao M V, Vasudev P, Srikant. Vitiligo: A part of a systemic autoimmune process, Indian J. Dermatol. Venereol. Leprol. 2007; 73(3):162– 5. https://doi.org/10.4103/0378-6323.32710. PMid: 17558047.
Liu J-B, Li M, Yang S, Gui J-P, Wang H-Y, Du W-H, et al. Clinical profiles of vitiligo in China: An analysis of 3742 patients, Clin. Exp. Dermatol. 2005 Jul; 30(4):327–31. https://doi.org/10.1111/j.1365-2230.2005.01813.x. PMid: 15953059.
Daneshpazhooh M, Mostofizadeh GM, Behjati J, Akhyani M, Robati RM. Anti-thyroid peroxidase antibody and vitiligo: A controlled study, BMC Dermatol. 2006 Dec 10; 6(1):3. https://doi.org/10.1186/1471-5945-6-3. PMid: 16526964, PMCid: PMC1431557.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.