Fabrication of TiO2-Carbon Paste Modified Electrochemical Sensor for 4-Aminophenol in Pharmaceutical Samples

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Authors

  • Gidey Bahre
     ,ET
  • Tadele Hunde
     ,ET
  • Mekonen Tirfu
     ,ET
  • Rishi Pal
     ,IN
  • R. C. Saini
     ,ET

DOI:

https://doi.org/10.18311/jsst/2016/6603

Keywords:

4-Aminophenol, Cyclic Voltammetry, Commericial Drugs, TiO2-Carbon Sensor, Square Wave Voltammetry.

Abstract

In this study the electrochemical behavior of 4-aminophenol at titanium dioxide modified carbon paste electrode was investigated using cyclic voltammetry. The working parameters for both, cyclic- and square wave- voltametric studies have been optimized using 5.0 mM 4-aminophenol (4-APOH) in 0.1 M NaH2PO4.2H2O buffer solution. The modified rather than unmodified carbon paste sensor, in neutral medium, has exhibited strong electro-catalytic activity towards the redox characteristics of 4-aminophenol by showing two-fold peak current enhancement and 174 mV peak potential shift towards negative direction. The red-ox peak current ratio (I pa/I pc = 1.6) suggested high accumulation efficiency of 4-APOH at the modified sensor. The redox process is quasi reversible and involves the transference of 2e-s and 2H+s followed by diffusion controlled, non-adsorptive behavior of 4-APOH on the surface of sensor at the interface. Further, the electro-catalytic behavior of the modified sensor has been exploited for quantitative determination of 4-aminophenol in pharmaceutical samples using square wave voltammetry. Under optimal experimental conditions, there was a linear relationship between peak current and concentration in the range 2.5 í— 10-5 to 2.0 í— 10-4 M with a correlation coefficient of 0.998 and limit of detection 1.38 í— 10-8 M. The method was successfully applied for the quantitative determination of 4-aminophenol in pharmaceutical formulations against the commercial drugs viz., PANADOL, and Paracetamol at recovery level of 100 ± 1.7 %.

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Published

2016-07-06

How to Cite

Bahre, G., Hunde, T., Tirfu, M., Pal, R., & Saini, R. C. (2016). Fabrication of TiO<sub>2</sub>-Carbon Paste Modified Electrochemical Sensor for 4-Aminophenol in Pharmaceutical Samples. Journal of Surface Science and Technology, 32(1-2), 60–68. https://doi.org/10.18311/jsst/2016/6603

Issue

Volume 32, Issue 1-2, June 2016

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2016-06-28
Accepted 2016-06-28
Published 2016-07-06

 

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