Synthesis of Gelatin Nanoparticles via Simple Coacervation


Affiliations

  • Jawaharlal Nehru University, School of Physical Sciences, New Delhi, 110067, India
  • Bhabha Atomic Research Centre, Solid State Physics Division, Mumbai, 400085, India
  • Paul Scherrer Institute, Villigen, CH-5232, Switzerland

Abstract

Dynamic light scattering (DLS), Transmission electron microscopy (TEM) and Small Angle Neutron Scattering (SANS) experiments are performed on biodegradable gelatin nanoparticles for size measurements and stability analysis. Though gelatin nanoparticles were previously prepared by the desolvation method [1], the simple coacervation [2] process is being proposed as a new and simple method to prepare very small and stable nanoparticles. Gelatin nanoparticles were found to have spherical conformation by transmission electron microscopy having a typical diameter 45±5nm, which was supported by dynamic light scattering data. This is very small compared to the same reported earlier for this polypeptide (∼200nm). Electrophoresis measurement showed that the nanoparticles present in the supernatant are negatively charged.

Keywords

Gelatin, Nanoparticle, Light and Neutron Scattering, Transmission Electron Microscopy and Electrophoresis.

Subject Discipline

Chemistry

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