Surface Properties of Amphiphilic Drugs in Presence of Cationic Surfactants

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Authors

  • School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.) ,IN
  • School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.) ,IN
  • School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.) ,IN
  • Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan ,IN
  • Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan ,IN
  • School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.) ,IN

DOI:

https://doi.org/10.18311/jsst/2014/1845

Keywords:

Amphiphilic Drug, Additives, Cationic Surfactant, Surface Properties, Surface Tension.

Abstract

Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (Γmax), minimum area per surfactant molecule at the air-water interface (Amin) and the surface pressure at the CMC (πCMC) have been determined. Γmax value increases and CMC/πCMC decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.