Insilico and Pharmacological Property Analysis of Bioactive Components from Prunus avium against Diabetics

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Authors

  • L. Veerapandi
     Department of Food Technology, Saintgits College of Engineering, Kottukulam, Pathamuttom Hills, Kottayam – 686532, Kerala ,IN
  • T. Nivetha
     Department of Food Technology, Hindusthan College of Engineering and Technology, Coimbatore – 641050, Tamil Nadu ,IN
  • R. Sinthiya
     Department of Food Technology, Processing Technology and Management, PSGR Krishnammal College for Women, Coimbatore – 641004, Tamil Nadu ,IN
  • N. Karunyah Amirthadharshini
     Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu ,IN
  • K. Bumaasri
     Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu ,IN
  • R. Aishwarya
     Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/jnr/2022/27660

Keywords:

Anthocyanins, Diabetes, Molecular Docking, Pancreatic alpha-amylase (4X9Y), Phytochemicals, β-amylase
PHARMACOLOGICAL PROPERTY ANALYSIS OF BIOACTIVE COMPONENT

Abstract

Diabetes is a common metabolic disorder, which effects people across all cultures globally. Lifelong distress is the cause of this disease which has no cure as of now. Various medications available in the market are too expensive and not easily affordable by all. Rural people rely on plant based Ayurvedic medications to heal diabetes as these contain anti-diabetic compounds. These phytoconstituents/anthocyanin derivatives work with several mechanisms that involve phytoconstituent interactions and target molecules in diabetic metabolism. Molecular docking analysis aids in finding out the interaction between receptors and ligands to identify the finest interaction which suits the target. In this case, the study proposed examining the bonding interactions of anti-diabetic compounds/anthocyanin derivatives derived from medicinal plants (Pelargonidin, Cyanidin, Delphinidin, Peonidin, Petunidin, Quercetin and pancreatic alpha-amylase (4X9Y)) with the help of the computational tool. ADME/T test helps decide different pharmacological and physicochemical analysis of lead atoms, degree of adsorption inside the cell, digestion rate, solvency, blood cerebrum boundary penetrability, cancer-causing nature and so on, which are the significant essentials prior to advertising a medication. Peonidin and Quercetin was proposing the best interactions. Nonetheless, to discover a better cure for diabetes, further in-vitro/ in vivo studies have to be carried out.

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Published

2022-02-14

How to Cite

Veerapandi, L., Nivetha, T., Sinthiya, R., Karunyah Amirthadharshini, N., Bumaasri, K., & Aishwarya, R. (2022). Insilico and Pharmacological Property Analysis of Bioactive Components from <i>Prunus avium</i> against Diabetics. Journal of Natural Remedies, 22(1), 113–119. https://doi.org/10.18311/jnr/2022/27660

Issue

Volume 22, Issue 1, January 2022

Section

Short Communication
Crossref
Scopus
Google Scholar
Europe PMC
Received 2021-04-20
Accepted 2021-10-20
Published 2022-02-14

 

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