A Review on the Biological Effects of some Natural Products


  • Sumandeep Vidyapeeth Deemed to be University, Piparia, Department of Pharmacy, Vadodara, Gujarat, 391760, India
  • Sumandeep Vidyapeeth Deemed to be University, Department of Pharmacy, Vadodara, Gujarat, 391760, India
  • Parul University, Parul Institute of Pharmacy & Research, Vadodara, Gujarat, 391760, India


This review is a compilation of a number of preclinical studies of the natural products for their biological activities. Many natural products studied for their biological activities are either in the form of herbal formulations or plant extracts. They showed antihypertensive, antilipidemic, antidiabetic, antioxidant, antianxiety, hepatoprotective, and many other activities. Many post graduate and doctoral students took part in studying the biological activities of these natural products. This comprehensive review will give an impetus for young research workers to explore the possibility of more biological activities on these natural products for the future studies to combat diseases.


Antioxidants, Hepatoprotective, Herbal Medicine, Ischemia Reperfusion, Natural Products, Type 2 Diabetes

Subject Discipline


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Balaraman R, Hingorani N, Rathod SP. Studies of antihypertensive effects of abana in rats. Indian Journal of Pharmacology. 1993; 25:209–14.

Bopanna KN, Bhagyalakshmi N, Rathod SP, Balaraman R, Kannan J. Cell culture derived from Hemidesmus indicus in the prevention of hypercholesterelomia in normal and hyperlipidemic rats. Indian Journal of Pharmacology. 1997; 29(2):105–9.

Khandelwal VKM, Balaraman R, Ondrejcakova M, Pancza D, Ravingerova T. Effect of Hemidesmus indicus on ischemia-reperfusion injury in the isolated rat heart. Pharmaceutical Biology. 2010; 48(6):611–14. https://doi.org/10.3109/13880200903218943. PMid:20645732

Kumar V, Khandelwal M, Balaraman R, Pancza D, Ravingerova T. Hemidesmus indicus and Hibiscus rosasinensis affect ischemia reperfusion injury in isolated rat hearts. Evidence-based Complementary and Alternative Medicine. 2011:1–8. https://doi.org/10.1155/2011/802937. PMid:20953394. PMCid:PMC2952330

Bopanna KN, Balaraman R, Kannan J, Gadgil S. Antidiabetic and antihyperlipidemic effect of neem seed kernel powder on alloxan induced diabetic rabbits. Indian Journal of Pharmacology. 1997; 29(3):162–7.

Upasani CD, Khera A, Balaraman R. Effect of lead with vitamin E, C or spirulina on malondialdehyde, conjugated diene and hydroperoxides in rats. Indian Journal of Experimental Biology. 2001; 39:70–4.

Upasani CD, Balaraman R. Protective effects of spirulina on lead induced deleterious changes in lipid peroxidation and endogenous antioxidants in rats. Phytotherapy Research. 2003; 17:330–4. https://doi.org/10.1002/ptr.1135. PMid:12722134

Mehta K, Balaraman R, Amin AH, Bafna PA, Gulati OD. Effects of fruits of Moringa oleifera on lipid profile of normal and hypercholesterolaemic rabbits. Journal of Ethnopharmacology. 2003; 86:191–5. https://doi.org/10.1016/S0378-8741(03)00075-8

Balaraman R, Pallavi AB, Kolhapure SA. Antioxidant activity of DHC-1 a herbal formulation. Journal of Ethnopharmacology. 2004; 94(1):135–141. https://doi.org/10.1016/j.jep.2004.05.008. PMid:15261974

Bafna PA, Balaraman R. Antioxidant activity of DHC-1 herbal formulation in experimentally induced cardiac and renal damage. Phytotherapy Research. 2005; 19:216–21. https://doi.org/10.1002/ptr.1659. PMid:15934019

Majithiya JB, Paramar AN, Balaraman R. Effect of curcumin on triton WR 1339 induced hypercholesterolemia in mice. Indian Journal of Pharmacology. 2004; 36(6):382–3.

Gandhi C, Zalawadia R, Balaraman R. Effect of curcumin in the prevention of experimentally induced nephrolithiasis in rats by Ethylene glycol and Vit.D3. Oriental Pharmacy and Experimental Medicine 2009; 9(3):259–67. https://doi.org/10.3742/OPEM.2009.9.3.259

Majithiya JB, Balaraman R. Time dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin induced diabetic rats treated with curcumin. Journal of Cardiovascular Pharmacology. 2005; 46(5):697– 705. https://doi.org/10.1097/01.fjc.0000183720.85014.24. PMid:16220078

Shah P, Upagalawankar A, Balaraman R. Combined cardioprotective effect of quercetin and curcumin on induced cardiotoxicity in rats. Pharmacognosy Magazine. 2008; 4(16):S246–50.

Majithiya JB, Balaraman R, Giridhar R, Yadav MR. Effect of bis[curcumino]oxovanadium complex on non-diabetic and streptozotocin-induced diabetic rats. Journal of Trace Elements in Medicine and Biology. 2005; 18:211–17. https:// doi.org/10.1016/j.jtemb.2004.12.001. PMid:15966569

Patil LJ, Balaraman R. Effect of green tea extract on cisplatin induced oxidative damage on kidney and testes of rat. Ars Pharmaceutica. 2005; 46:5–18.

Patil L, Balaraman R. Protective effect of green tea extract on doxorubicin induced cardiotoxicity in rats. Oriental Pharmacy and Experimental Medicine. 2005; (5):137–43. https://doi.org/10.3742/OPEM.2005.5.2.137

Upaganlawar A, Gandhi C, Balaraman R. Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats. Plant Foods for Human Nutrition. 2008; 64(1):75–80. https://doi.org/10.1007/ s11130-008-0105-9. PMid:19058010

Patil LJ, Balaraman R. Green tea extract protects doxorubicin induced testicular damage in rats. International Journal of PharmTech Research. 2009; 1(3):879–84.

Bafna PA, Balaraman R. Antiulcer and antioxidant activity of Pepticare, a herbomineral formulation. Phytomedicine 2005; 12(4):264–70. https://doi.org/10.1016/j.phymed.2003.12.009. PMid:15898703

Koneri R, Balaraman R, Saraswati CD. Antiovulatary, Abortifacient potential of the ethanolic extract of roots of Momordica cymbalaria Fenzl in rats. Indian Journal of Pharmacology. 2006; 8(2):111–14. https://doi.org/10.4103/0253-7613.24616

Koneri R, Saraswati CD, Balaraman R, Ajeesha EA. Anti-implantation activity of the ethanolic root extract of Momordica cymbalaria Fenzl in rats. Indian Journal of Pharmacology. 2007; 39: 90–6. https://doi.org/10.4103/0253-7613.32527

Balaraman R, Koneri R. Antidiabetic mechanisms of Saponins of Momordica cymbalaria. Pharmacognosy Magazine. 2008; 4(15):197–206.

Koneri R, Balaraman, Firdous, Kumar MV. Hepatoprotective effects of Momordica cymbalaria Fenzl. against carbon tetrachloride induced hepatic injury in rats). Pharmacologyonline. 2008; 1:365–74.

Dangwal S, Mohan M, Balaraman R. Antihypertensive effect of Trigonella foenum- greacum seeds in experimentally induced hypertension in rats. Pharmaceutical Biology. 2006; 44(8):1–8. https://doi.org/10.1080/13880200600896538

Mohan M, Kasture SB, Balaraman R. Anxiolytic activity of standarised extract of Korean ginseng – a study on exploratory behaviour. Oriental pharmacy and Experimental Medicine. 2005; 5(4):301–7. https://doi.org/10.3742/OPEM.2005.5.4.301

Zalawadia R, Balaraman R. Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumininduced experimental allergic conjunctivitis in rats. Oriental Pharmacy and Experimental Medicine. 2009; 9:58–66. https://doi.org/10.3742/OPEM.2009.9.1.058

Zalawadia R, Balaraman R. The protective effect of Tinospora Cordifolia Linn. on various mast cell-mediated allergic reactions. Pharmaceutical Biology. 2009; 47(11):1096–106. https://doi.org/10.3109/13880200903008690

Gandhi C, Upaganlawar A, Balaraman R. Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by Hesperidin. Free Radical Research. 2009; 43:817–27. https://doi.org/10.1080/10715760903071656. PMid:19579067

Gandhi C, Zalawadia R, Balaraman R. Hesperidin improves warm Ischemia/Reperfusion-Induced Oxidative Renal Injury in Rats. Oriental Pharmacy and Experimental Medicine. 2009; 9:292–302. https://doi.org/10.3742/ OPEM.2009.9.4.292

Upaganlawar A, Balaraman R. Cardioprotective effects of Lagenaria siceraria fruit juice on isoproterenol induced myocardial infarction in Wistar Rats: A biochemical and histoarchitecture study. Journal of Young Pharmacists. 2011; 3:297–303. https://doi.org/10.4103/0975-1483.90241.

PMid:22224036. PMCid:PMC3249742

Upaganlawar A, Patel V, Balaraman R. Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti-apoptotic study. Asian Pacific Journal of Tropical Biomedicine. 2012; 2:345–51. https://doi.org/10.1016/S2221-1691(12as)60054-9

Parmar G, Pundarikakshudu K, Balaraman R. Antianaphylactic and antithmatic activity of Euphorbia thymifolia L. on experimental animals. Journal of Traditional and Complementary Medicine. 2019; 9(1): 60–5. https:// doi.org/10.1016/j.jtcme.2018.03.002. PMid:30671367. PMCid:PMC6335472

Parmar G, Pundarikakshudu K, Balaraman R, Sailor G. Amelioration of anaphylaxis, mast cell degranulation and bronchospasm by Euphorbia hirta L. extracts in experimental animals. Beni-Suef University Journal of Basic and Applied Sciences. 2018; 7(1):127–34. https://doi.org/10.1016/j.bjbas.2017.11.001

Parmar GR, Pundarikakshudu K, Balaraman R. Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats. Journal of Applied Pharmaceutical Science. 2017; 7(08):78–84.

Shukla D, Maheshwari RA, Patel K, Balaraman R, Sen AK. Effect of Vaccinium macrocarpon on MK801 induced psychosis in mice. Indian Journal of Pharmacology. 2018; 50:227–35. https://doi.org/10.4103/ijp.IJP_74_17. PMid:30636825. PMCid:PMC6302693


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