Anti-hyperglycaemic Effect of Aegle marmelos (L.) in Animal Experiments-PRISMA based Systematic Review and Meta-analysis

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Authors

  • Department of Agada Tantra and Vyavaharayurveda (Toxicology, Jurisprudence and Forensic Medicine), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Vallikavu – 690546, Kerala ,IN
  • Department of ENT, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi – 682041, Kerala ,IN
  • Department of Rasasastra and Bhaishajya Kalpana (Medicinal Chemistry and Pharmacy), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Vallikavu – 690546, Kerala ,IN
  • Amrita Centre for Advanced Research in Ayurveada, Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Vallikavu – 690546, Kerala ,IN

DOI:

https://doi.org/10.18311/jnr/2019/23676

Keywords:

Ayurveda, Diabetes, Prameha, Vilwa

Abstract

Aegle marmelos is a folklore medicine which is widely consumed as an anti-hyperglycaemic drug, its properties are known since prehistoric times. Plenty of cell line as well as animal research have reported the anti-hyperglycaemic activity of the drug. Even though quality researches are necessary to fulfil further human studies and marketing, no quality assessments for these studies have been undertaken till date. The aim was to critically analyse the quality standards and evaluate the anti-hyperglycaemic potential of A. marmelos in rodent model researches. The search strategy was done using the key words ‘Aegle marmelos, along with ‘Diabetes or Hyperglycaemia,' in different databases like PubMed (n = 45), Google Scholar (n = 43) and Science Direct (n = 46). However, the filter used during the search was ‘Animal experimentation'. All animal experimentations collected with the keyword search was analysed for the inclusion criteria like serum glucose estimation as primary outcome, timeline of publication 1997 to 2017 in English and treatments containing any part and any form of A. marmelos in single or in combination. Based on the inclusion criteria, 11 articles were selected for the review. Data extraction underwent a blind procedure independently by two reviewers. If full texts were not available, communicating the authors was also tried and all the four authors responded. All the studies selected after screening were given unique codes, to ensure blind review. Result observed indicated higher reduction of serum glucose levels in hyperglycaemia-induced rodent models. After administering the drug, significant changes were observed in total cholesterol as well as triglycerides. Rest of the LDL, HDL, SOD and serum insulin were an in-significant find. Sample size calculation was not mentioned in any of the studies. Only 9% of the studies reported on blinding and 18% reported on randomisation. This might have affected the internal validity of the studies. It can be concluded that A. marmelos is effective in lowering the serum glucose levels in experimental hyperglycaemia. Further research has to be conducted to explore its target specific mode of action. This may lead to the development of an effective anti-hyperglycaemic drug with minimal side effects.

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Published

2020-01-03

How to Cite

Mohan, P., Kumar, M., Misra, A., & Rammanohar, P. (2020). Anti-hyperglycaemic Effect of <i>Aegle marmelos</i> (<i>L</i>.) in Animal Experiments-PRISMA based Systematic Review and Meta-analysis. Journal of Natural Remedies, 19(4), 169–180. https://doi.org/10.18311/jnr/2019/23676

Issue

Section

Review Articles
Received 2019-05-08
Accepted 2019-09-23
Published 2020-01-03

 

References

McEwen LN, Kim C, Haan M, Ghosh D, Lantz PM, Mangione CM, et al. Diabetes reporting as a cause of death: Results from the Translating Research Into Action for Diabetes (TRIAD) study. Diabetes Care. 2006 Feb 1; 29(2):247–53. https://doi.org/10.2337/diacare.29.02.06.dc0 5-0998. PMid:16443868

Bordoloi R, Dutta KN. A review on herbs used in the treatment of diabetes mellitus. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014; 2(22):86–92.

Firenzuoli F, Gori L. Herbal medicine today: Clinical and research issues. Evid Based Complement Alternat Med. 2007 Sep; 4(Suppl 1):37–40. https://doi.org/10.1093/ecam/ nem096. PMid:18227931 PMCid:PMC2206236

Kamath SD. Study on medicinal plants and drugs of Dhanwanthari nighantu: Choukambha Orientalia publications; 2002.

Jermiin LS, Ho SYW, Ababneh F, Robinson J, Larkum AWD. Points of view the biasing effect of compositional heterogeneity on phylogenetic estimates may be underestimated. Systematic Biology. 2004; 53(4):638– 43. https://doi.org/10.1080/10635150490468648. PMid:15371251

Riley RD, Ensor J, Jackson D, Burke DL. Deriving percentagestudy weights in multi-parameter meta-analysis models: with application to meta-regression, network metaanalysis and one-stage individual participant data models. SMMR. 2018 Mar 20; 1–20.

Durg S, Dhadde SB, Vandal R, Shivakumar BS, Charan CS. Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: A systematic review and meta-analysis. Journal of Pharmacy and Pharmacology. 2015; 67(7):879–99. https://doi. org/10.1111/jphp.12398. PMid:25828061

Hooijmans CR, Rovers MM, Bm De Vries R, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC. 2014; 14–23. https://doi.org/10.1186/1471-2288-14-43. PMid:24667063 PMCid:PMC4230647

Hafizur RM, Momin S, Fatima N. Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos. BMC Complement AlternMed. 2017 Apr 21;17(1):227. https://doi.org/10.1186/ s12906-017-1743-y. PMid:28431540 PMCid:PMC5399853

Mudi SR, Akhter M, Biswas SK, Muttalib MA, Choudhury S, Rokeya B, et al. Effect of aqueous extract of Aegle marmelos fruit and leaf on glycemic, insulinemic and lipidemic status of type 2 diabetic model rats. Journal of Complementary and Integrative Medicine. 2017 Mar 9; 14(2). https://doi.org/10.1515/jcim-2016-0111. PMid:28284036

Ansari P, Afroz N, Jalil S, Azad S Bin, Mustakim MG, Anwar S, et al. Anti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption. Journal of Pediatric Endocrinology and Metabolism. 2017; 30(1):37–47. https://doi.org/10.1515/jpem-2016-0160. PMid:28002030

Saravanan M, Pandikumar P, Saravanan S, Toppo E, Pazhanivel N, Ignacimuthu S. Lipolytic and antiadipogenic effects of (3,3-dimethylallyl) halfordinol on 3T3-L1 adipocytes and high fat and fructose diet induced obese C57/ BL6J mice. European Journal of Pharmacology. 2014 Oct 5; 740:714–21. https://doi.org/10.1016/j.ejphar.2014.06.004. PMid:24952133

Manik S, Gauttam V, Kalia AN. Anti-diabetic and antihyperlipidemic effect of allopolyherbal formulation in OGTT and STZ-induced diabetic rat model. Indian Journal of Experimental Biology. 2013 Sep; 51(9):702–8.

Kumar V, Ahmed D, Verma A, Anwar F, Ali M, Mujeeb M. Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. An ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity. BMC Complementary and Alternative Medicine. 2013; 13(1):273. https://doi.org/10.1186/1472-6882-13-273. PMid:24138888 PMCid:PMC3833852

Bhatti R, Sharma S, Singh J, Singh A, Ishar MPS. Effect of Aegle marmelos (L.) Correa on alloxan induced early stage diabetic nephropathy in rats. Indian Journal of Experimental Biology. 2013; 51(6):464–9.

Ramesh B, Pugalendi KV. Influence of umbelliferone on glycoprotein components in diabetic rats. Toxicol Mech Methods. 2007; 17(3):153–9. https://doi.org/10.1080/15376510600899555. PMid:20020964

Upadhya S, Shanbhag KK, Suneetha G, Balachandra Naidu M, Upadhya S. A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats. Indian Journal of Physiology and Pharmacology. 2004; 48(4):476–80.

Gholap S, Kar A. Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie. 2004; 59(11):876– 8.

Kamalakkannan N, Prince PSM. Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats. Indian Journal of Experimental Biology. 2003; 41(11):1285–8.

Bhyan N, Mitra T, Mohanty JP, Pawanka G. Phytochemical and pharmacological activity of Aegle marmelos as a potential. SMMR. 2018 Mar 20:11–43.

Maity P, Hansda D, Bandyopadhyay U, Kumar Mishra D. Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L.) Corr. Indian Journal of Experimental Biology. 2009; 47:849–61.

Laphookhieo S, Phungpanya C, Tantapakul C, Techa S, Tha-In S, Narmdorkmai W. Chemical Constituents from Aegle marmelos. Journal of the Brazilian Chemical Society. 2011; 2(1):176–8.

Hesen NA, Riksen NP, Aalders B, Ritskes-Hoitinga M, Messaoudi S El, Wever KE. A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction, SMMR. 2017 Mar 20:11–30. https://doi.org/10.1371/journal.pone.0183664. PMid:28832637 PMCid:PMC5568412