Biochemical Assessment of Possible Protective Role of Kombucha Tea against Stressful Effect Induced by High Sucrose Dose


Affiliations

  • Department of Biochemistry, Benha University, Egypt
  • Benha University, Department of Biochemistry, Egypt
  • Shaqra University, Department of Basic Medical Sciences, Saudi Arabia

Abstract

Kombucha tea is highly fermented beverage popularly consumed in many countries. The aim was to evaluate the possible protective effects of the usage of Kombucha as natural agent against the stressful effects resulted from administration of high sucrose diet to male rabbits through determination of some biochemical parameters. The results demonstrated that pretreatment with Kombucha tea in high sucrose stressed rabbit significantly improve lipid profile and antioxidant system meanwhile significant reduction of glucose, urea, creatinine, cupper and non significant change in testosterone and copper levels. In conclusion, Kombucha tea was able to ameliorate serum biochemical parameters in high sucrose stressed rabbits mediated by antioxidant and lipotropic properties.

Keywords

Antioxidant, Anti-Atherosclerotic Effect, Hypoglycemic Effect, Rabbit.

Full Text:

References

Atwa SA. Biochemical study of Kombucha in Quail. [MSc. thesis in Biochemistry]. Fac Vet Med; Benha University; 2010.

Anuradha CV, Anurag P. Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats. Diabetes Obes Metab. 2002; 4:36–42. PMid: 11874440. https://doi.org/10.1046/j.14631326.2002.00178.x

Besty P, Sanford H. Kombucha phenomenon the miracle health tea how to safely make and use Kombucha. 2nd ed. Sierra. 2016.

Brows E. Changes in free radical scavenging ability of Kombucha tea during fermentation. Food Chemistry. 2008; 109(I):227–34.

Busserolles J, Zimowska W, Rock E, Rayssiguier Y, Mazur A. Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression. Life Sci. 2002; 71:1303–12. https://doi.org/10.1016/S00243205(02)01846-5

Chen C, Liu BY. Changes in major components of tea fungus metabolites during prolonged fermentation.

Journal of Applied Microbiology. 2000; 89(5):834–9. PMid: 11119158. https://doi.org/10.1046/ j.1365-2672.2000.01188.x

Mohammed EH, Ruiz-Ramírez A, Chavez-Salgado M, Pe-eda-Flores JA, Zapata E,. Masso F. High-sucrose diet increases ROS generation, FFA accumulation, UCP2 level and proton leak in liver mitocondria. Am J Physiol Endocrinol Metab. 2011; 301(6):E1198–207. PMid: 21917631. https://doi.org/10.1152/ajpendo.00631.2010

El-Tabbakh IM. Effect of olive leaves and oil on some biochemical constituents in rabbits fed on high sucrose ration. [PhD Thesis in Biochemistry]. Fac Vet Mede. Alexandria University. 2014.

Hartmann AM, Burleson LE, Holmes AK, Geist CR. Effects of chronic Kombucha ingestion on open-field behaviors, longevity, appetitive behaviors and organs in c57-bl/6 mice: A pilot study. Nutrition. 2000; 16(9): 755–61. https://doi.org/10.1016/S0899-9007(00)00380-4

Wan H, Nikolas D, O’Doherty Robert M. Hepatic steatosis and plasma dyslipidemia induced by a high-sucrose diet are corrected by an acute leptin infusion. J Appl Physiol. 2007; 102:2260–5. PMid: 17363621. https://doi.org/10.1152/japplphysiol.01449.2006

Ibrahiem AA, ELsayed EM, Hafez SA, El-Zeini HM, Salah FA. The hypocholestermic effect of milk yoghurt and soy-yoghurt containing bifido bacteria in rat fedon a cholesterol enriched diet. International Dairy Journal. 2005l 15(1):37–44. https://doi.org/10.1016/j.idairyj.2004.06.001

Kalo MS. Effect of cholesterol biosynthesis inhibitor on some biochemical parameters in normal male rats. Iraqi Journal of Veterinary Sciences. 2009; 23(1):5–12. https://doi.org/10.33899/ijvs.2009.5684

Kamari Y, Harari A, Shahish A, Peleg E, Sharabi Y, Harats D, Grossman E. Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructoseinduced hypertensive, hyperinsulinemic, hyperlipidemic rats. Hypertens Res. 2008; 3:135–40. PMid: 18360028. https://doi.org/10.1291/hypres.31.135

Kaneko JJ. Kaneko JJ, Harvey JW, Bruss ML. Clinical biochemistry of domestic animals. San Diego, CA: Academic Press p. 46 ISBN 012370491. 2008.

Lee CP, Shih PH, HSV CL, Yen GC. Hepatoprotection of tea seed oil (camellia oleifera Abel) against CCH. Induced oxidative damage in rats. Food and Chemical Toxicology. 2007; 45:888–95. PMid: 17188414. https://doi.org/10.1016/j.fct.2006.11.007

Liu CH, Hsu WH, Lee FL, Liao CC. Isolation and identification of microbes from a fermented tea beverage, Hapiao and their interaction during Haipao fermentation. Food Microbiology. 1996; 13(6):407–15. https://doi.org/10.1006/fmic.1996.0047

L’opez-Miranda J, Badim’on L, Bonanome A, Lairon D, Kris-Etherton PM, Mata P, et al. Monounsaturated fat and cardiovascular risk. Nutr Rev. 2016; 64(2):2–12.

Maurya SK, Srivastava AK. High fructose diet-induced glucose intolerance and dyslipidemia in adult Syrian golden hamsters. Indian Journal of Science and Technology. 2008; 1(6):1–5.

Nandhini AT, Thirunavukkarasu V, Ravichandran MK, Anuradha CV. Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. Singapore Med J. 2005; 46(2):82–7. PMid: 15678290.

Ola AG. Effect of Kombucha on oxidative stress induced nephro toxicity in rats. Chin Med. 2009; 4:23.

PMid: 19943946 PMCid: PMC2788564. https://doi.org/10.1186/1749-8546-4-23

Radomir V, Malbasa RV, Eva S. lancan and ljitjana A. Kolarov. Tea fungus fermentation a substrate with iron (II) ions. Acta Periodica Technologica. 2002; 33:143–9.

Ram M, Anju B, Pauline T, Dipti P, Kain AK, Mongiass, Sharmask, Singh B, Singh R, Ilavazhagan G, Kumar D, Selvamurthyw. Effect of Kombucha tea on chromate induced oxidative stress in albino rats. J Ethnopharmacol. 2000; 71(1-2):235–40. https://doi.org/10.1016/S03788741(00)00161-6

Shalaby MA, el-Zorba HY, Kamel GM. Effect of alpha tocopherol and simvastatin on male fertility in hypercholesterolemic rats. Pharmacol Res. 2004; 50(2):137–42. PMid: 15177301. https://doi.org/10.1016/j.phrs.2003.10.013

Srividhya S, Anuradha,C. Metformin improves liver antioxidant potential in rats fed a high-fructose diet. Asia Pacific J Clin Nutr. 2007; 11(4):319–22. PMid: 12495266. https://doi.org/10.1046/j.1440-6047.2002.00306.x

Stanhope KL, Griffen S, Krauss RM, et al. Consumption of fructose-, but not glucose-sweetened beverages produces an atherogenic lipid profile in overweight/obese men and women. J Clin Invest. 2007; 119:1322–34. PMid: 19381015 PMCid: PMC2673878. https://doi.org/10.1172/JCI37385

Suzuki T, Hara H. Ingestion of guar gum hydrolysate, a soluble and fermentable non digestible saccharide, improves glucose intolerance and prevents hypertriglyceridemia in rats fed fructose. J Nutr. 2004; 134(8):1942–7. PMid: 15284380. https://doi.org/10.1093/jn/134.8.1942

Taniguchi M, Cherian MG. Antigenic changes in hepatic glutathione and metallothionein in rats and the effect of a low sulfur containing diet. Br J Nutr. 2010; 63:97–103. https://doi.org/10.1079/BJN19900095

Yousef NS. Tea extracts as possible natural food preservative for organic food. Acta Hortic. 2003; 608:169–76. https://doi.org/10.17660/ActaHortic.2003.608.21

Zhi-Wei Y, Baping FZ, Boli YC, Liyang T. The hypocholestermic and antioxidants effects of Kombucha tea in high cholesterol fed mice. Journal of the Science of Food and Agriculture. 2009; 89:150–6. https://doi.org/10.1002/jsfa.3422


Refbacks

  • There are currently no refbacks.