Antidiabetic Effect of Picralima nitida Aqueous Seed Extract in Experimental Rabbit Model

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Authors

  • ,NG
  • ,NG
  • ,NG
  • ,NG

DOI:

https://doi.org/10.18311/jnr/2001/22

Keywords:

Picralima nitida, Antidiabetic Activity, Alloxan.
Therapeutic Drug Monitoring

Abstract

Objective: The blood sugar lowering effect of P. nitida aqueous seed extract was investigated on normoglycaemic and hyperglycaemic rabbits. Materials and methods: The hypoglycaemic effect of P. nitida was evaluated using alloxan (80 mg/kg body weight, i.p) induced hyperglycaemic rabbits. The extracts potency was compared with standard drug, tolbutamide and distilled water. The LD50 was determined using mice. Results: A dose of 648 mg/kg body weight of extract caused maximum lowering of blood sugar levels in both normal and alloxanized rabbits. The mean fasting blood sugar in the normoglycaemic rabbit was reduced by 19.46% within 3 h, while in alloxanized rabbits blood sugar level was reduced by 75.5% within 6 h. The LD50 of the extract in mice was 1601.2 ± 60.5 mg/kg body weight when given i.p. Conclusion: P. nitida, though a crude drug, exhibited a faster onset of action and more persistent in hyperglycaemic situation than tolbutamide standard controls. This qualifies it to be used in ethnomedical diabetic management.

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Published

2001-07-01

How to Cite

Aguwa, C. N., Ukwe, C. V., Inya-Agha, S. I., & Okonta, J. M. (2001). Antidiabetic Effect of <I>Picralima nitida</I> Aqueous Seed Extract in Experimental Rabbit Model. Journal of Natural Remedies, 1(2), 135–139. https://doi.org/10.18311/jnr/2001/22

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