Anti-Nociceptive Activity of Mundulea sericea Leaves

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  • ,IN
  • ,IN
  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2004/175

Keywords:

Mundulea sericea, Analgesic, Tail Immersion, Writhing.
Therapeutic Drug Monitoring

Abstract

Objective: To study the analgesic activity of leaves of Mundulea sericea. Methods: Methanolic extract (30 mg/kg and 70 mg/kg) of Mundulea sericea (Leguminosae, subfamily Papilionaceae) was investigated for analgesic activity using acetic acid-induced writhing and tail immersion method. The extract was studied for its effect on pentobarbitone-induced sleep and on gross behavior. Results: Methanolic extract (30 mg/kg and 70 mg/kg) significantly increased latency to flick tail in tail immersion test and reduced the number of writhings induced by acetic acid. The extract increased the duration of pentobarbitone-induced sleep. No adverse effects were observed upto a dose of 200 mg/kg of the extract. Conclusion: Leaves of Mundulea sericea possess central as well as peripheral analgesic activity.

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Published

2004-06-01

How to Cite

Iyer, M., Karode, R., Deshmukh, R., & Deshmukh, V. (2004). Anti-Nociceptive Activity of <I>Mundulea sericea</I> Leaves. Journal of Natural Remedies, 4(2), 127–130. https://doi.org/10.18311/jnr/2004/175

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