Effect of Sesamum indicum oil in Thyroidectomy-Induced Erectile Dysfunction in Rat


Affiliations

  • Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Department of Pharmaceutical Sciences, Dehradun, Uttarakhand, 248161, India

Abstract

The aim of the present study has been to explore the effect of Sesamum indicum in thyroidectomy-induced erectile dysfunction in rat. The animals were anaesthetized with combination of midazolam and ketamine i.p., and the thyroid gland was dissected out. The skin was then stitched and the wound was closed. Animals were treated with penicillin injection i.p. for 5 days postoperatively. After 45 days of surgery different groups of animals were treated with sesamum oil at dose levels 2 mL, 3 mL and 5 mL/kg p.o., and with standard drug sildenafil, respectively, for 28 days. At the end of the study erectile dysfunction-associated physical and biochemical parameters were evaluated to assess the effect of Sesamum indicum in thyroidectomy-induced erectile dysfunction. Thyroidectomy resulted in impairment of sexual function in the rat. Treatment of Sesamum indicum oil caused increase in testosterone level. It also produced significant positive effects on the physical parameters of sexual function such as mount latency, intromission latency, ejaculatory latency, post-ejaculatory interval, mount frequency and intromission frequency. Though the oil did not produce any significant effect on the levels of thyroid hormones, the oil at the doses of 2 mL, 3 mL and 5 mL/kg body weight restored sexual competence to a reasonable extent in which the highest dose produced the maximum response. A combination of Sesamum indicum oil and thyroxin may be recommended for hypothyroidism-associated sexual impairment.

Keywords

Erectile dysfunction, Sesamum indicum, Sesamum oil, Thyroidectomy, Thyroxine.

Subject Discipline

Pharmacology

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