Assessment of Serum Vitamin D Levels in Patients with Pulmonary Tuberculosis-A Comparative Cross Sectional Study in a Teritiary Care Centre in Kolar


Affiliations

  • Sri Deveraj Urs Academy of Higher Education and Research, Division of Internal Medicine, Kolar, Karnataka, 563 101, India
  • Sri Deveraj Urs Academy of Higher Education and Research, Division of Biochemistry and Crop Physiology, Kolar, Karnataka, 563 101, India

Abstract

Tuberculosis remains as one of the deadliest disease affecting humankind and vitamin D deficiency is a global health problem. The evidence is increasingly pointing towards increased susceptibility to TB among individuals with vitamin D deficiency and worse disease progression if infected with TB. Hence the current study was undertaken to assess the prevalence of vitamin D deficiency in patients with pulmonary tuberculosis and to compare it with non-tuberculosis cases. This study was a comparative cross-sectional study conducted in R.L. Jalappa hospital among 100 individuals divided into two groups. Group 1 consisted of 70 sputum positive pulmonary TB case and group 2 consisted of 30 community healthy controls matched for age and gender. The subjects were investigated for biochemical parameters and serum vitamin D level using Electro-chemiluminescence Immuno Assay (ECLIA). The mean age of TB and non-TB cases was 52.53 ± 15.68 years and 56.07 ± 10.06 years respectively. Mean vitamin D level in the study population were 29.51± 28.19 ng/ml. Vitamin D deficiency was found in 54 (77.14%) cases with TB and in 10 (33.33%) non-TB cases. The mean difference in serum albumin (3.89 ± 0.89 g/dl vs 3.42 ± 0.76 g/dl); calcium levels (7.3 ± 1.59 mg/dl vs 8.5 ± 1.37 mg/dl) and vitamin D level (22.02 ± 23.8 ng/ml vs 47 ± 30.22 ng/ml) were statistically significant (p value < 0.01) across the group. This study concludes that vitamin D deficiency is associated with an increased prevalence of tuberculosis. This recommends the screening for vitamin D deficiency and encourages vitamin D supplementation for all tuberculosis patients.

Keywords

Vitamin D Deficiency, Tuberculosis, Non-Tuberculosis, Immunity, Vitamin D2.

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