Clinical Profile and Response to First-Line Anti-Retroviral Therapy in Human Immunodeficiency Virus Infected Patients in Manipur
Objectives: This retrospective study was conducted on HIV patients in Manipur, to assess clinical profile and factors influencing baseline immunological status and response to ART.
Methodology: 1231 patients were enrolled. Baseline demographic and laboratory parameters were recorded. CD4 cell counts were recorded at baseline and 6 months after ART initiation.
Results: 66.3% patients were male, 74.6% aged 21-40 years, 65.6% were Hindus and 52.9% of urban residence. 17.5% patients had Haemoglobin ≤9 grams/dl. Prevalence of HIV-HBV and HIV-HCV coinfection was 3.4% and 20.5% respectively. Male sex (141.51±96.21 vs. 169.92±111.2 cells/mm3; p=0.001), age >20 years and Haemoglobin ≤9 g/dl (127.5±99.5 vs. 153.8±99.1cells/mm3; p=0.001) were associated with lower baseline CD4 count. Females (219.01±187.2 vs. 161.79±153.35cells/mm3; p=0.001), age group 1-20 years and those without HIV-HCV coinfections (188.72±170.81 vs. 154.20±155.88 cells/mm3; p=0.004) had significant improvement in CD4 count at 6 months-post ART initiation. CD4 response in HIV-HBV coinfected patients was lower (188.59±170.65 vs. 162.39±139.8 cells/mm3; p=0.324) but not statistically significant.
Conclusion: Majority of HIV patients in Manipur were - Males, Hindus, aged 21-40 years and of urban residence. Males, age >20 years and haemoglobin ≤9 g/dl were associated with lower baseline CD4 count. HIVHBV/ HIV-HCV coinfection wasn't associated with lower baseline CD4 count. Females, age <20 years and absence of HIV-HBV/HIV-HCV coinfections were associated with superior immunological response to ART.
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