A Study on Concordance of Pre and Post-surgical Biopsy in Oral Carcinoma


Affiliations

  • Mahe Institute of Dental Sciences and Hospital, Department of Oral Medicine & Radiology, Pondicherry, India
  • Malabar Cancer Centre Thalassery, Department of Surgical Oncology, Kannur, Kerala, India
  • Pariyaram Dental College, Department of Oral Pathology, Kerala, India
  • King Khalid University, Department of Diagnostic Science & Oral Biology, College of Dentistry, Abha, Saudi Arabia
  • King Khalid University, Department of Diagnostic Science & Oral Biology, College of Dentistry, Abha, India
  • Daswani Dental College & Research Hospital, Department of Oral Medicine & Radiology, Kota, Rajasthan, India

Abstract

Background: Clinically suspicious oral lesions are usually first dealt with an incisional biopsy. The management and treatment plan of these entities depends mainly on this report. The disparity in incisional and excisional biopsy report is an important area of concern affecting the patient’s management.

Objective: Aim of the study was to compare retrospectively the incisional (presurgical) and excisional (post-surgical) biopsy reports of proven cases of carcinomas.

Material and Methods: A total of 98 excisional biopsy cases of proved oral carcinoma were selected. Both incisional and excisional biopsy reports were retrieved. Sex predilection, Frequency of site of tumor, correlation between incisional and excisional biopsy, type of biopsy and change in the status were studied and statistically analyzed. Significance between Pre-biopsy and post biopsy was statistically analyzed using Chi-Square Tests.

Results: There was concordance of 66.3% in incisional and excisional biopsy report. 33.7% cases showed disparity. Upgrading in the excisional biopsy report was noted in 15.30% cases. Downgrading was noted in 14.26% cases. When statistically analyzed the difference in pre-and post-biopsy was statistically insignificant.

Conclusion: Incisional biopsy was found to have certain restriction in the valuation of Oral lesions. Clinicians should be vigilant the possibility of under diagnosis from incisional biopsy and even undetected carcinoma in the incisional specimen, especially of nonhomogeneous lesions.


Keywords

Incisional Biopsy, Concordance, Disparity, Oral Carcinoma, Excision.

Subject Discipline

Dentistry

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References

Poh CF, Samson Ng, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and Histopathologic Diagnosis of Oral Premalignant and Malignant Lesions. J Can Dent Assoc 2008;74(3):283-8.

Bailey JS, Blanchaert RH, Ord RA. Management of oral squamous cell carcinoma treated with inadequate excisional biopsy. J Oral Maxillo fac Surg 2001;59:1007–10.

Lee J, Hung H, Cheng SJ, Chiang CP, Liu BY, Yu CH, et al. Factors associated with under diagnosis from incisional biopsy of oral leukoplakic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:217-25.

Giunta J, Meyer I, Shklar G. The accuracy of the oral biology in the diagnosis of cancer. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1969;28:552-6.

Pentenero M, Carrozzo M, Pagano M, Galliano D, Broccoletti R, Scully C, et al. Oral mucosal dysplastic lesions and early squamous cell carcinomas: under diagnosis from incisional biopsy. Oral Dis 2003; 9:68-72.

Lee JJ, Hung HC, Cheng SJ, Chen YJ, Chiang CP, Liu BY, et al. Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:472-80.

Sylvie-Louise Avon SL, Klieb H. Oral SoftTissue Biopsy: An Overview. J Can Dent Assoc 2012;78:c75.

AN Goss, RM Logan. Biopsy of the oral mucosa and use of histopathology services Australian Dental Journal 2010;55:9–13.

Oliver RJ, Sloan P, Pemberton MN. Oral biopsies: methods and applications. Br Dent J 2004;196(6):329-33.

Onofre MA, Sposto MR, Navarro CM. Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:535-40.

Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:321-9.


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