Anxiolytic and Antiepileptic Activity of Aerial Parts of Flemingia macrophylla in Rodents


Affiliations

  • SRM University, SRM College of Pharmacy, Chennai, Tamil Nadu, India

Abstract

The present study was underta ken to evaluate the anxiolytic and anti epileptic activity of ethonolic extract of Flemingia macrophylla by using different extract conce ntrations in rodents . A nxiolytic activity of FME was estimated by using Elevated plus maze test and light - dark model a long with Mono Amino Oxidase enzyme levels in mice and the anticonvulsant activity of FME was estimated in rats by using MES , PTZ methods and those showing response were divided into four groups of six animals each. Group - I (Normal), Group - II (Diazepam 2 mg/ Kg , p.o) , Group - III (FME 20mg/Kg in mice, 100mg/Kg in rats, p.o), Group - IV(FME 50mg/Kg in mice, 200mg/Kg , p.o). Animals treated with FME had shown a significant increase in enzyme levels and significant decrease in anxiety and onset of convulsions w hen compared with the diazepam treated animals. T he ethanolic extract of Flemingia macrophylla afforded significant protection against anxiety and epilepsy. The activity may be due to the presense of flavonoids & glycosides.

Keywords

Anti Anxiety, Anti Epileptic, Flemingia macrophylla, Diazepam, Pentylene Tetrazole.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

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