Casein Controversy in Carcinoma

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Authors

  • Tumpa Pal
     West Bengal State University, Department of Food & Nutrition, Berunanpukuria, Malikapur, Kolkata - 700126, Barasat, West Bengal ,IN
  • Samadrita Sengupta
     West Bengal State University, Department of Food & Nutrition, Berunanpukuria, Malikapur, Kolkata - 700126, Barasat, West Bengal ,IN

DOI:

https://doi.org/10.24906/isc/2020/v34/i1/195948

Keywords:

Casein, Caseinmicelles, Bioactive Peptides, Carcinogenic Agent, Anticarcinogenic Agent, Mortality Risk.

Abstract

Casein is the major protein part of milk. It is used in different industrial aspects. In this writeup different types of casein protins responsible for different types of cancer have been highlighted. Some anticarcinogenic properties due to its bioactive components which help in reducing the proliferation of cancer cells have been presented.

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Published

2020-01-01

How to Cite

Pal, T., & Sengupta, S. (2020). Casein Controversy in Carcinoma. Indian Science Cruiser, 34(1), 14–20. https://doi.org/10.24906/isc/2020/v34/i1/195948

Issue

Volume 34, Issue 1, January 2020

Section

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References

A. Sharp.2016. Milk and Cancer – prevention or Promotion. Dairy myths part 4. Abbey’s Kitchen

A. Taha, M. Koshiyama, N. Matsumura, K. Abiko, K. Yamaguchi, J. Hamanishi, T. Baba, B. Kharma, I.H. Mohamed, M.M. Ameen, S.A. Ismail, I. Konishi and M. Mandai. 2018. The effect of the type of dietary protein on the development of ovarian cancer.Oncotarget Open Access Journal, 9 (35). doi: 10.18632/oncotarget.25253

J. Ali. 2014. To investigate the amount of casein present in various milk samples of mammalian milks to provide a practical alternative to cow in allergic patients. Mayo Clinic Staff.

A. Krosel. 2019. Dairy dangers: Is sheep, goat dairy healthier than cow dairy? Copyright of gene food.

A. Badem, and G. Ucar, 2017. Production of Caseins and Their Usage. International Journal of Food Science and Nutrition, 2, 04-09. doi.org/10.22271/ food.

M.Y. Baht, T. A. Dar, and L.R. Singh, 2016. Casein Proteins: Structural and Functional Aspects, Creative Common Attribution 3.0 License.

G. Bonucelli, R.Castorella, F. Capozza, Ue. Martinez-Outschroon, Z. Lin, A. Tsirigos, J.Xuanmao, D. Whitekar-Menezes, A. Howell, M. P. Lisanti, and F. Sotgia 2012. The milk protein alpha- casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis, Cell Cycle, 11 (21), 3972-82.doi: 10.4161/cc.22227.

D. E. Corpet, Y. Yin, X. M. Zhang, C. Remesy, D.Stamp, A. Medline, L.U. Thomson, W. R.Bruce, and M. C. Archer, 2008. Colonic Protein Fermentation And Promotion Of Colon Carcinogenesis By Thermolyzed Casein.Nutrition and Cancer, 23. doi: 10.1080/01635589509514381.

K. R. Ellfahri, T. Vasiljevic, T. Yeager, O. N. Donkor, 2016. Anti-Colon Cancer And Antioxidant Activities Of Bovine Skim Milk Fermented By Selected Lactobacillus Helveticus Strain. Journal of Dairy Science. 99 31–40 Http://Dx.Doi.Org/10.3168/Jds.2015-10160.

G. Bounccelli, R.C. Cros, F. Capozza, U. E.Martinez-Outschoorn, Z. Lin, A. Tsirigos, J.Xuanmao, D. Whitaker-Menezes, A. Howell, M.P.Lisanti, And F. Stogia, 2012. The Milk Protein Alpha Casein Functions As Tumor Suppressor Via Activation Of Stat 1 Signaling, Effectively Preventing Breast Cancer Tumor Growth And Metastasis, Cell Cycle, 11 (21); 3972-3982.

K. Yao, H. Youn, X. Gao. B. Huang, F. Zhou, B.Li, and H. Han, 2012. Casein Kinase-2 inhibition Attenuates Androgen Receptor Function and Cell Proliferation In Prostate Cancer Cells.The Prostate, 72, 13.Https://Doi.Org/10.1002/ Pros.22493.

K. Kent, 2003. Eat Your Whey: It May Protect Against Prostate Cancer. Ohio State University.

K.Z. Wynn Lae, and A.A. Cho, 2011. Extraction of Casein and Determination of Its Components From Three Kinds Of Milk. Universities Research Journal, 4, No. 3.

L. Kral, 2017.An ancient variety of milk might do wonders for digestion or it could be a money grab.The Health Battle behind America’s Next Milk Trend.

C.P. Kulkamini, 2017. Analysis of Casein precipitation from the various milk samples available in market. International Journal of Food Science and Nutrition, 2, 215-216.

A. Kumasean, C. Selma, N.V. Reshma, and N.A Jacinth, 2017. Qualitative Analysis of Casein Preparation from the various milk samples.Journal of Chemical and Pharmaceutical Research, 9 (9): 113-115.

Y. Li, J. Yu, 2015. Research progress in structure-activity relationship of bioactive peptides. Journal of Medicinal Food, 18(2), 147–56. doi: 10.1089/jmf.2014.0028.

R.S. Macdonald, W.H. Thornton, and R. T.Marshall, 1994. A cell culture model to identify biologically active peptides generated by bacterial hydrolysis of casein. Journal of Dairy Science, 77(5) 1167-75.

S. Majid, 2016.Bioactive components in milk and dairy products. Swedish University of Agricultural Sciences.

M. Metropulos, 2017. A2 milk: What you need to know. Medical News Today.

S. Malihe, B. Mandana, and M. Hassan, 2017. Anticancer activity of cow, sheep, goat, mare, donkey and camel milks and their caseins and whey proteins and in silico comparison of caseins. Molecular Biology Research Communications, 2, 57-64.

U. Muro, A. Fernandez, R. Riera, C. Arana, and J. Tellez, 2011. Production and functionally of active peptides from milk. Food Science and Technology International, 4, 293-317.DOI: 10.1177/1082013211398801.

H. Nada, A. Al-Mudalla, Q. Madlen, and I. Farooq, (2016). Growth Inhibition and Anti-Cancer Activity of the Human Hepatocarcinoma HepG2 Cell Line in Vitro Study Using Human, Camel and Cow Milk. International Journal of Sciences: Basic and Applied Research, 30, No. 2, 40-47.

R. Nall, 2018. Cancer causes cells to divide uncontrollably. This can result in tumors, damage to the immune system, and other impairment that can be fatal, what to know about cancer. American Cancer Society.

T.A. Nicklas, C.E. O’neil, V. L. Fulgoni, 2009. The role of dairy in meeting the recommendations for shortfall nutrients in the American diet. Journal of American College of Nutrition, 73-81.

L.M. Newmark, 2018. Milk Casein Proteins: Ancient, Diverse, and Essential. International Milk Genomics Consortium.

Oliveira,Mj. Damme, Jv, Lauwaet, T. Corte, V, (2003).Beta-casein-Derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. The EMBO Journal, 22, 6161-6173.

S.W.Park, Jy.Kim, and M. Chung, 2014.A milk Protein Casein as a Proliferation Promoting Factor in Prostate Cancer. The World Journal of Men’s Health, 32(2): 76-82.doi: 10.5534/ wjmh.2014.32.2.76.

P.W. Parodi, 2007. A role for milk proteins and their peptides in cancer prevention. Journal of Cancer Therapy, 13, No. 8, 813-828. doi: 10.2174/138161207780363059.

K. Patel, 2013. Examine.com Research Team last updated 2018.https://examine.com/supplements/ casein- protein.

T. Rachel, T. Carr, G. Gischolar_main, 2018. Understanding Medical Decision-making in Prostate Cancer Care. American Journal of Men’s Health, https://doi.org/10.1177/1557988318780851.

S.Silberstein, 2015. What causes ovarian cancer-part-3? Beat cancer.org.

P.Tate, L. Bibb, 2011. Milk Stimulated growth of prostate cancer cells in culture, Nutrition and Cancer.

M. Tatsuta, H.Iishi, M.Baba, H.Tanuguchi, 1992. Enhanced induction of colon carcinogenesis by azoxymethane in Wistar rats fed a low-protein diet, International Journal of Cancer. 50(1):108-11.

A.Tellez, M.Corredig, Ly.Brovko, Mv.Griffiths, 2010. Characterization of immune active peptides obtained from milk fermented by lactobacillus helveticus. Journal of Dairy Research. 77 (2). 129-36,.doi: 10.1017/S002202990999046X.

W. Wang, G. Fang, W. Cai, T. Yigui, Z. Xin, and R. Mingqiang 2013.PGPIPN, a Therapeutic Hexa-peptide, Suppressed Human, Ovarian Cancer Growth by Targeting BCL2, plos.org.https://doi.org/10.1371/journal.pone.0060701.

L Wei, C. Hanwen, N.Yuequn, W.Han, X. Dajing, W.Yihua, 2016. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutrition Journal,1 5, doi: 10.1186/s12937-016-0210-9.

K. Xu, M. Ling, X.Wang, and Y.Wong, 2006. Evidence of a novel biomarker, alpha s1- casein, a milk protein, in benign prostate hyperplasia.Prostate Cancer and Prostatic Disease, 9, 293-297.

M. Yang, Sa.Kenfield, El. Van Blarigan, Km.Wilson, Jl.Batista, Hd.Sesso, J.Ma, Mj.Stampfer, Je.Chavarro, 2015. Dairy intake after prostate cancer diagnosis in relation to disease-specific and total mortality. International Journal of Cancer. 137 (10): 2462-9, doi: 10.1002/ijc.29608.

J.Yan, Zy.Wang, Hz. Yang, Hz. Liu, S. Mi, 2011. Timing is critical for an effective anti-metastatic immunotherapy: the Decisive Role Of Ifnγ/STAT1-Mediated Activation of Autophagy. Plos.

P.Zangerle, A.Thirion, JC. Hendrick, P. Franchimont, 1978. Casein and other tumor markers in relation to cancer of the breast, PubMed.gov, 22, 141-8.